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Am J Physiol Regul Integr Comp Physiol (March 25, 2004). doi:10.1152/ajpregu.00723.2003
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Submitted on December 19, 2003
Accepted on March 17, 2004

Y1- and {alpha}1-receptor control of basal hindlimb vascular tone

Dwayne N Jackson1, Earl G Noble1, and J. Kevin Shoemaker1*

1 Neurovascular Research Laboratory, Faculty of Health Science, School of Kinesiology, The University of Western Ontario, London, Ontario, Canada

* To whom correspondence should be addressed. E-mail: kshoemak{at}uwo.ca.

The role of endogenous Y1-receptor activation on skeletal muscle vasculature under baseline conditions is currently debated and no in vivo studies have been performed to address this issue. Therefore, this study was designed to address the effect of Y1-receptor and/or {alpha}1-adrenoceptor antagonism on basal hindlimb vascular conductance in male Sprague-Dawley rats in vivo. Left hindlimb vascular conductance, carotid artery mean arterial pressure, and heart rate were measured during low volume infusion of BIBP3226 (100 µg/kg), prazosin (20 µg/kg), and combined blockade to the left hindlimb. Vascular conductance increased 1.5 ± 0.5 µl/min/mmHg with BIBP3226 infusion, 1.7 ± 0.5 µl/min/mmHg with prazosin infusion, and 4.8 ± 1.0 µl/min/mmHg with combined blockade (P < 0.05). Interestingly, systolic vascular conductance increased in all 3 conditions, but diastolic vascular conductance only increased in the two conditions where BIBP3226 was present. These data indicate that Y1-receptor activation plays an important role in the regulation of vascular conductance in the resting rat hindlimb. Furthermore, this effect was of the same magnitude as the {alpha}1-adrenoceptor contribution. The differential flow profiles following {alpha}1 blockade with and without Y1-receptor blockade supports local differences in receptor distribution.




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