AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol (April 4, 2002). doi:10.1152/ajpregu.00675.2001
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
283/2/R331    most recent
00675.2001v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ruijtenbeek, K.
Right arrow Articles by De Mey, J. G. R.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Ruijtenbeek, K.
Right arrow Articles by De Mey, J. G. R.

Articles in PresS, published online ahead of print April 4, 2002
Am J Physiol Regu Physiol, 10.1152/ajpregu.00675.2001
Submitted on November 12, 2001
Accepted on March 28, 2002

Direct effects of acute hypoxia on the reactivity of peripheral arteries of the chicken embryo

K. Ruijtenbeek1, C. G. A. Kessels1, E. Villamor1, C. E Blanco1, and J. G. R. De Mey2*

1 Department of Pediatrics, Research Institute Growth and Development (GROW), University Hospital Maastricht and Maastricht University, Maastricht, Limburg, The Netherlands
2 Department of Pharmacology & Toxicology, Cardiovascular Research Institute Maastricht(CARIM), University Hospital Maastricht and Maastricht University, Maastricht, Limburg, The Netherlands; School of Life Sciences, Transnational University Limburg, Maastricht, Limburg, The Netherlands

* To whom correspondence should be addressed. E-mail: J.DeMey{at}farmaco.unimaas.nl.

In the chicken embryo, acute hypoxemia results in cardiovascular responses, including an increased peripheral resistance. We investigated whether local direct effects of decreased oxygen tension might participate in the arterial response to hypoxemia in the chicken embryo. Femoral arteries of chicken embryos were isolated at 0.9 of incubation time and the effects of acute hypoxia on contraction and relaxation were determined in vitro. While hypoxia reduced contraction induced by high K+ to a small extent (-21.8±5.7%), contractile responses to exogenous norepinephrine (NE) were markedly reduced (-51.1±3.2%) in 80% of the arterial segments. This effect of hypoxia was not altered by removal of the endothelium, inhibition of NO synthase or cyclo-oxygenase, nor by depolarization plus Ca2+-channel blockade. When arteries were simultaneously exposed to NE and acetylcholine (Ach), hypoxia resulted in contraction (+49.8±9.3%). Also, relaxing responses to Ach were abolished during acute hypoxia, while the vessels became more sensitive to the relaxing effect of the NO-donor, sodium nitroprusside (pD2: 5.81±0.21 vs. 5.31±0.27). Thus, in chicken embryo peripheral arteries, acute hypoxia blunts agonist-induced contraction of the smooth muscle and inhibits stimulated EDRF release. The consequences of this for in vivo fetal hemodynamics during acute hypoxemia depend on the balance between vasomotor influences of circulating catecholamines and those of the endothelium.




This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
H. Greyner and E. M. Dzialowski
Mechanisms mediating the oxygen-induced vasoreactivity of the ductus arteriosus in the chicken embryo
Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2008; 295(5): R1647 - R1659.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
C. Torres-Farfan, F. J. Valenzuela, M. Mondaca, G. J. Valenzuela, B. Krause, E. A. Herrera, R. Riquelme, A. J. Llanos, and M. Seron-Ferre
Evidence of a role for melatonin in fetal sheep physiology: direct actions of melatonin on fetal cerebral artery, brown adipose tissue and adrenal gland
J. Physiol., August 15, 2008; 586(16): 4017 - 4027.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
N. Igosheva, P. D. Taylor, L. Poston, and V. Glover
Prenatal stress in the rat results in increased blood pressure responsiveness to stress and enhanced arterial reactivity to neuropeptide Y in adulthood
J. Physiol., July 15, 2007; 582(2): 665 - 674.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
E. A. Herrera, V. M. Pulgar, R. A. Riquelme, E. M. Sanhueza, R. V. Reyes, G. Ebensperger, J. T. Parer, E. A. Valdez, D. A. Giussani, C. E. Blanco, et al.
High-altitude chronic hypoxia during gestation and after birth modifies cardiovascular responses in newborn sheep
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2007; 292(6): R2234 - R2240.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
D. G. Hemmings, S. J. Williams, and S. T. Davidge
Increased myogenic tone in 7-month-old adult male but not female offspring from rat dams exposed to hypoxia during pregnancy
Am J Physiol Heart Circ Physiol, August 1, 2005; 289(2): H674 - H682.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
S. J. Williams, M. E. Campbell, I. C. McMillen, and S. T. Davidge
Differential effects of maternal hypoxia or nutrient restriction on carotid and femoral vascular function in neonatal rats
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2005; 288(2): R360 - R367.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
K. Ruijtenbeek, J. G. R. De Mey, C. E. Blanco ;, and H. Ehmke
The Chicken Embryo in Developmental Physiology of the Cardiovascular System: A Traditional Model with New Possibilities
Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2002; 283(2): R549 - R551.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 2002 by the American Physiological Society.