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Articles in PresS, published online ahead of print October 17, 2002
Am J Physiol Regu Physiol, 10.1152/ajpregu.00640.2001
Submitted on October 31, 2001
Accepted on October 3, 2002
1 Medicine, University of Texas Health Science Center, San Antonio, TX, USA
2 Pathology, University of Texas Health Science Center, San Antonio, TX, USA
3 Physiology, University of Texas Health Science Center, San Antonio, TX, USA
4 Physiology, University of Texas Health Science Center, San Antonio, TX, USA; Research Service, South Texas Veterans Health Care System, Audie L. Murphy Division, San Antonio, TX, USA
5 Medicine, University of Texas Health Science Center, San Antonio, TX, USA; Geriatric Research, Education and Clinical Center, South Texas Veterans Health Care System, Audie L. Murphy Division, San Antonio, TX, USA
* To whom correspondence should be addressed. E-mail: katz{at}uthscsa.edu.
Loss of weight, often of unknown cause and culminating in death, commonly occurs in people at advanced ages. Rats, such as the F344 strain, that live to old ages also exhibit a terminal loss in body weight. A currently held hypothesis is that the terminal weight loss in the F344 rat model is due to reduced food intake because of an alteration in hypothalamic function resulting in early satiation. This communication reports findings on terminal weight loss and food intake in male F344 rats fed either ad libitum (AL group) or a life prolonging dietary regimen in which caloric intake was restricted (DR group). Rats in both dietary groups that did not exhibit a terminal weight loss died at younger ages than those exhibiting the loss. Terminal weight loss in the AL group was not associated with decreased food intake; indeed, half of the rats in this group had an increased food intake during the period of terminal weight loss. This finding is not in accord with the currently held hypothesis. In the DR group, terminal weight loss was associated with reduced food intake. Pathology (renal disease and neoplasms) did not explain the presence or absence of the association between reduced food intake and weight loss in either dietary group. The duration of the period of terminal weight loss was similar for the AL and DR groups. Apparently, restricting calories delays the occurrence but does not affect the duration of senescent terminal weight loss.
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