AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol (June 27, 2002). doi:10.1152/ajpregu.00620.2001
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
283/5/R1041    most recent
00620.2001v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bertram, D.
Right arrow Articles by Lo, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bertram, D.
Right arrow Articles by Lo, M.

Articles in PresS, published online ahead of print June 27, 2002
Am J Physiol Regu Physiol, 10.1152/ajpregu.00620.2001
Submitted on October 11, 2001
Accepted on June 13, 2002

Differential evolution of blood pressure and renal lesions after renin-angiotensin system blockade in Lyon hypertensive rats

Delphine Bertram1, Nelly Blanc-Brunat2, Jean Sassard1, and Ming Lo1*

1 Department of Physiology and Clinical Pharmacology, Faculty of Pharmacy, University of Lyon, Lyon, France
2 INSERM Unite, Hopital Edouard Herriot, Lyon, France

* To whom correspondence should be addressed. E-mail: mlo{at}rockefeller.univ-lyon1.fr.

The present work aimed to assess, in Lyon hypertensive (LH) rats, whether an early and prolonged inhibition of the renin-angiotensin system (RAS) could result in a blood pressure (BP) lowering and nephro-protection which persist after its withdrawal. Male LH rats received orally from 3 to 12 weeks of age, either an angiotensin converting enzyme (ACE) inhibitor, perindopril, at the doses of 0.4 and 3 mg/kg/day, or an AT1 receptor antagonist, losartan, at the dose of 10 mg/kg/day. BP, histological changes in the kidney and urinary protein excretion were examined during and 10 weeks after cessation of the treatments. Both perindopril and losartan decreased BP, prevented renal lesions and limited urinary protein excretion. After cessation of the treatment, BP returned to the level of never treated LH rats in rats having received the 3 mg/kg/day of perindopril while it remained slightly lower in those treated with 0.4 mg/kg/day of perindopril or with losartan. This lack of marked persistent antihypertensive effect contrasted with a durable decrease in urinary protein excretion and improvement of the renal histological lesions. In conclusion, it is possible to separate the BP lowering effects of RAS blockade from those on glomerulosclerosis and urinary protein excretion.




This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
A. Mate, A. Barfull, A. M. Hermosa, L. Gomez-Amores, C. M. Vazquez, and J. M. Planas
Regulation of sodium-glucose cotransporter SGLT1 in the intestine of hypertensive rats
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2006; 291(3): R760 - R767.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
D.-F. Guo, I. Chenier, J. L. Lavoie, J. S.D. Chan, P. Hamet, J. Tremblay, X. M. Chen, D. H. Wang, and T. Inagami
Development of Hypertension and Kidney Hypertrophy in Transgenic Mice Overexpressing ARAP1 Gene in the Kidney
Hypertension, September 1, 2006; 48(3): 453 - 459.
[Abstract] [Full Text] [PDF]

Home page
 HeartHome page
J E Toblli, G Cao, G DeRosa, and P Forcada
Reduced cardiac expression of plasminogen activator inhibitor 1 and transforming growth factor {beta}1 in obese Zucker rats by perindopril
Heart, January 1, 2005; 91(1): 80 - 86.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
P. B. Persson
The kidney and hypertension
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2003; 284(5): R1176 - R1178.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 2002 by the American Physiological Society.