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Am J Physiol Regul Integr Comp Physiol (July 18, 2002). doi:10.1152/ajpregu.00282.2002
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Articles in PresS, published online ahead of print July 18, 2002
Am J Physiol Regu Physiol, 10.1152/ajpregu.00282.2002
Submitted on May 18, 2002
Accepted on July 16, 2002

Sensitive periods for the effect of dietary sodium restriction on intact and denervated taste receptor cells

Lynnette Phillips McCluskey1* and David L Hill2

1 Department of Physiology, Medical College of Georgia, Augusta, GA, USA
2 Department of Psychology, University of Virginia, Charlottesville, VA, USA

* To whom correspondence should be addressed. E-mail: lmccluskey{at}mail.mcg.edu.

Unilateral chorda tympani nerve (CT) section combined with dietary sodium restriction leads to striking alterations in sodium taste function. The regenerated rat CT exhibits deficits in sodium sensitivity, and surprisingly, there are also functional alterations in the intact, contralateral nerve. The studies presented here describe the functional "sensitive periods" for these aberrations and the number of taste buds present during corresponding stages. The regenerated CT is sensitive to dietary sodium restriction during the first two weeks after denervation, while the intact CT is sensitive to dietary manipulation during the first week post-section. Therefore, distinct mechanisms are responsible for the effects of sodium restriction combined with denervation, since separate sensitive periods exist for the regenerated and intact CT nerves. Identification of mature taste buds with an antibody directed at anti-keratin 19 revealed that there is a loss of approximately 85% of taste buds on the denervated side of the tongue under control and low sodium diets within the first week post-section. Thus, sodium-restriction does not differentially affect the loss of taste buds following denervation.




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