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1 Departments of Psychiatry & Medicine, Columbia University, New York, New York, USA; Obesity Research Center, St. Luke's/Roosevelt Hospital, New York, New York, USA
2 Obesity Research Center, St. Luke's/Roosevelt Hospital, New York, New York, USA
* To whom correspondence should be addressed. E-mail: hrk2{at}columbia.edu.
The aim of this study was to test the hypothesis that gastric distension can enhance the effect of cholecystokinin (CCK) on reduction of food intake in men and women. Eight normal weight subjects of each gender were tested four times each with either CCK or saline infusion crossed with gastric distention or no distention. Intravenous infusion of a low dose of cholecystokinin octapeptide CCK-8 (112 ng/min for 23 min) combined with a sub-threshold gastric distention induced by a water-filled balloon (300 ml), resulted in a significant (191 g± 61 SED in men, 209 g ± 61 SED in women, 200 g ± 43 SED, combined) reduction in intake of a liquid meal compared to saline infusion and unfilled gastric balloon. CCK This combined effect was the result of large and significant CCK effect when the stomach was distended (CCK vs saline with distention = 169 g ± 43 SED) and a small and insignificant distention effect (distention vs no distention without CCK = 31 g ± 43 SED). The CCK effect alone on intake (CCK vs saline) without distention was not significant in men (72 g ± 61 SED), but was significant in women (121 g ± 61 SED). These results are consistent with the hypothesis that CCK's suppression of food intake is enhanced when the stomach is distended.
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