| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Articles in PresS, published online ahead of print July 18, 2002
Am J Physiol Regu Physiol, 10.1152/ajpregu.00151.2002
Submitted on March 7, 2002
Accepted on July 15, 2002
1 Circulatory Control Laboratory, Departments of Physiology and Electrical and Electronic Engineering, University of Auckland, Auckland, New Zealand
2 Department of Physiology, Monash University, Melbourne, Victoria, Australia
3 Biostatistics Unit, Division of Community Health, University of Auckland, Auckland, New Zealand
* To whom correspondence should be addressed. E-mail: roger.evans{at}med.monash.edu.au.
We tested for regional differences in perfusion responses, within the renal medulla and cortex, to renal nerve stimulation in pentobarbital anesthetized rabbits. Laser Doppler flux (LDF) was monitored at various depths below the cortical surface (1-15 mm). Basal cortical LDF (1-3 mm, ~200-450 units) was greater than medullary LDF (5-15 mm, ~70-160 units), but there were no statistically significant differences in basal LDF within these regions. The background LDF signal during aortic occlusion was similar in the cortex (2 mm, 31 units) and outer medulla (7 mm, 31 units), but slightly greater in the inner medulla (12 mm, 44 units). During electrical stimulation of the renal nerves (0.5-8 Hz), cortical LDF and total renal blood flow were similarly progressively reduced with increasing stimulus frequency. Medullary LDF (measured between 5 and 15 mm) was overall less responsive than cortical LDF. For example, 4 Hz stimulation reduced inner medullary LDF (9 mm) by 19±6 %, but reduced cortical LDF (1 mm) by 54±11 %. However, medullary LDF responses to nerve stimulation were similar at all depths measured. Our results indicate that while the vascular elements controlling medullary perfusion are less sensitive to the effects of electrical stimulation of the renal nerves than are those controlling cortical perfusion, sensitivity within these vascular territories appears to be relatively homogeneous.
This article has been cited by other articles:
|
|
 |
|
  R. G. Evans, S. L. Burke, G. W. Lambert, and G. A. Head Renal responses to acute reflex activation of renal sympathetic nerve activity and renal denervation in secondary hypertension Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2007; 293(3): R1247 - R1256. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.-L. Leong, W. P. Anderson, P. M. O'Connor, and R. G. Evans Evidence that renal arterial-venous oxygen shunting contributes to dynamic regulation of renal oxygenation Am J Physiol Renal Physiol, June 1, 2007; 292(6): F1726 - F1733. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. C. Malpas, R. Ramchandra, S.-J. Guild, D. M. Budgett, and C. J. Barrett Baroreflex mechanisms regulating mean level of SNA differ from those regulating the timing and entrainment of the sympathetic discharges in rabbits Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2006; 291(2): R400 - R409. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. M. O'Connor, M. M. Kett, W. P. Anderson, and R. G. Evans Renal medullary tissue oxygenation is dependent on both cortical and medullary blood flow Am J Physiol Renal Physiol, March 1, 2006; 290(3): F688 - F694. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. A. Eppel, S. E. Luff, K. M. Denton, and R. G. Evans Type 1 neuropeptide Y receptors and {alpha}1-adrenoceptors in the neural control of regional renal perfusion Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2006; 290(2): R331 - R340. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. W. Rajapakse, A. K. Sampson, G. A. Eppel, and R. G. Evans Angiotensin II and nitric oxide in neural control of intrarenal blood flow Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2005; 289(3): R745 - R754. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. M. Duke, G. A. Eppel, R. E. Widdop, and R. G. Evans Disparate Roles of AT2 Receptors in the Renal Cortical and Medullary Circulations of Anesthetized Rabbits Hypertension, August 1, 2003; 42(2): 200 - 205. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. B. Persson The kidney and hypertension Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2003; 284(5): R1176 - R1178. [Full Text] [PDF]
|
|
|
|
|
|
G. A. Eppel, G. Bergstrom, W. P. Anderson, and R. G. Evans Autoregulation of renal medullary blood flow in rabbits Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2003; 284(1): R233 - R244. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
