| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Articles in PresS, published online ahead of print August 1, 2002
Am J Physiol Regu Physiol, 10.1152/ajpregu.00127.2002
Submitted on February 26, 2002
Accepted on July 26, 2002
1 Department of Pediatrics, Medical University of South Carolina, Charleston, SC, USA; Department of Anesthesia and Critical Care, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA
2 Department of Cardiology, Children's Hospital and Harvard Medical School, Boston, MA, USA
3 Department of Pediatrics, Medical University of South Carolina, Charleston, SC, USA
* To whom correspondence should be addressed. E-mail: saulp{at}musc.edu.
Small negative changes of central volume reduce cardiac output without significant alterations of arterial blood pressure (ABP), suggesting an adequate regulatory response. Further, evidence has arisen supporting a Bainbridge reflex (tachycardia with hypervolemia) in humans. To investigate these phenomena, multivariate autoregressive techniques were used to evaluate the beat-to-beat interactions between respiration, RR interval and ABP at 6 levels of decreased and increased central volume. With reductions of central volume below control, baroreflex and respiratory sinus arrhythmia gains were reduced, while with increases of volume above control, gains increased for the first 2 levels, but decreased again at the highest volume level, suggesting the presence of a Bainbridge reflex in healthy human subjects. The mechanical influence of respiration on central venous pressure (CVP) had an unexpected shift in phase at the point of mild central hypervolemia, with the expected negative relation at lower volumes (inspiration lowers CVP), but a positive relation at higher volumes (inspiration raises CVP). Conclusions: Multivariate techniques can quantify the relations between a variety of respiratory and hemodynamic parameters, allowing for the in vivo assessment of complex cardio-respiratory interactions during manipulations of central volume. The results identify the presence of a Bainbridge reflex in humans, and suggest that short-term cardiovascular control is optimized at mild hypervolemia.
This article has been cited by other articles:
|
|
 |
|
  M. Benedetti, R. Rorato, M. Castro, B. H. Machado, J. Antunes-Rodrigues, and L. L. K. Elias Water deprivation increases Fos expression in hypothalamic corticotropin-releasing factor neurons induced by right atrial distension in awake rats Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2008; 295(5): R1706 - R1712. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Ramchandra, S. G. Hood, A. M. D. Watson, and C. N. May Responses of cardiac sympathetic nerve activity to changes in circulating volume differ in normal and heart failure sheep Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2008; 295(3): R719 - R726. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Novak, K. Hu, M. Vyas, and L. A. Lipsitz Cardiolocomotor Coupling in Young and Elderly People J. Gerontol. A Biol. Sci. Med. Sci., January 1, 2007; 62(1): 86 - 92. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Ogoh, R. M. Brothers, Q. Barnes, W. L. Eubank, M. N. Hawkins, S. Purkayastha, A. O-Yurvati, and P. B. Raven Effects of changes in central blood volume on carotid-vasomotor baroreflex sensitivity at rest and during exercise J Appl Physiol, July 1, 2006; 101(1): 68 - 75. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Ogoh, R. M. Brothers, Q. Barnes, W. L. Eubank, M. N. Hawkins, S. Purkayastha, A. O-Yurvati, and P. B. Raven Cardiopulmonary baroreflex is reset during dynamic exercise J Appl Physiol, January 1, 2006; 100(1): 51 - 59. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Barbieri, E. C. Matten, A. A. Alabi, and E. N. Brown A point-process model of human heartbeat intervals: new definitions of heart rate and heart rate variability Am J Physiol Heart Circ Physiol, January 1, 2005; 288(1): H424 - H435. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. J. Gates, S. E. Mateika, R. C. Basner, and J. H. Mateika Baroreflex Sensitivity in Nonapneic Snorers and Control Subjects Before and After Nasal Continuous Positive Airway Pressure Chest, September 1, 2004; 126(3): 801 - 807. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. M. Stauss Heart rate variability Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2003; 285(5): R927 - R931. [Full Text] [PDF]
|
|
|
|
|
|
M. Rohdin, J. Petersson, P. Sundblad, M. Mure, R. W. Glenny, S. G. E. Lindahl, and D. Linnarsson Effects of gravity on lung diffusing capacity and cardiac output in prone and supine humans J Appl Physiol, July 1, 2003; 95(1): 3 - 10. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
