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Articles in PresS, published online ahead of print August 15, 2002
Am J Physiol Regu Physiol, 10.1152/ajpregu.00040.2002
Submitted on January 23, 2002
Accepted on July 17, 2002
1 Veterans Affairs Medical Center, Minnesota Obesity Center, Minneapolis, MN, USA; Department of Psychiatry, University of Minnesota, Minneapolis, MN, USA; Department of Psychology, University of Minnesota, Minneapolis, MN, USA
2 Veterans Affairs Medical Center, Minnesota Obesity Center, Minneapolis, MN, USA
3 Department of Psychology, University of Minnesota, Minneapolis, MN, USA; Psychology, University of Minnesota, Minneapolis, MN, USA
4 Veterans Affairs Medical Center, Minnesota Obesity Center, Minneapolis, MN, USA; Department of Medicine, University of Minnesota, Minneapolis, MN, USA; Medicine, University of Minnesota, Minneapolis, MN, USA
* To whom correspondence should be addressed. E-mail: ALLENL{at}umn.edu.
We hypothesized that the opioid antagonist naltrexone would inhibit the re-development of a preference for a high sucrose diet after an abstention period from this diet. Rats that chose between a starch or sucrose diet for 10 days preferred the sucrose diet. Rats were then given access to the starch diet alone for another 10 day period. A mini-osmotic pump containing saline or naltrexone was then implanted (70 µg/hr; 1.7 mg/day) for about 10 days. During the saline infusion 77% of the total energy came from the sucrose diet whereas during the naltrexone infusion 33% of the total energy came from the sucrose diet. We repeated this study in another group of rats; however did not restrict the sucrose diet. In this case naltrexone failed to decrease preference for the sucrose diet. Thus, naltrexone infusion inhibited re-development of a preference for a sucrose diet after a period of restriction to a starch diet for ten days, but had no effect on preference if both diets were present throughout the study.
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