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Fig. 2. Prostaglandin-induced changes in membrane potential and AHP. PGD2 and PGE2 were applied by local pressure ejection (1 s, 10-4 M). Both prostaglandins produced a biphasic membrane response (A and B) of a brief hyperpolarization followed by a more prolonged depolarization. In addition, action potentials collected in these same cells before and just after prostaglandin application showed a decrease in AHP duration after PGD2 or PGE2 application. Resting membrane potentials were A and C, -50 mV; B and D, -40 mV.
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