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This Article Full Text Full Text (PDF) All Versions of this Article: 291/6/R1638    most recent 00241.2006v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Ogata, H. Articles by Yamamoto, Y. Search for Related Content PubMed PubMed Citation Articles by Ogata, H. Articles by Yamamoto, Y.

APPETITE, OBESITY, DIGESTION, AND METABOLISM

Long-range negative correlation of glucose dynamics in humans and its breakdown in diabetes mellitus

¹Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan; ²Division of Endocrinology and Metabolism, Department of Medicine, Jichi Medical School, Tochigi, Japan; and ³Educational Physiology Laboratory, Graduate School of Education, The University of Tokyo, Tokyo Japan

Submitted 7 April 2006 ; accepted in final form 25 July 2006

Diurnal fluctuations in glucose levels continuously monitored during normal daily life are investigated using an extended random walk analysis, referred to as detrended fluctuation analysis (DFA), in 12 nondiabetic subjects and 15 diabetic patients. The DFA exponent = 1.25 ± 0.29 for healthy individuals in the "long-range" (>2 h) regime is shown to be significantly (P < 0.01) smaller than the reference "uncorrelated" value of = 1.5, suggesting that the instantaneous net effects of the dynamical balance of glucose flux and reflux, causing temporal changes in glucose concentration, are long-range negatively correlated. By contrast, in diabetic patients, the DFA exponent = 1.65 ± 0.30 is significantly (P < 0.05) higher than that in nondiabetic subjects, evidencing a breakdown of the long-range negative correlation. It is suggested that the emergence of such positive long-range glucose correlations in diabetic patients—indicating that the net effects of the flux and reflux persist for many hours—likely reflects pathogenic mechanisms of diabetes, i.e., the lack of long-term stability of blood glucose and that the long-range negatively correlated glucose dynamics are functional in maintaining normal glucose homeostasis.

continuous glucose monitoring system; detrended fluctuation analysis; positive/negative correlation