HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 289/6/R1675    most recent 00412.2005v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (9) Citing Articles via Google Scholar Google Scholar Articles by Hajnal, A. Articles by Bello, N. T. Search for Related Content PubMed PubMed Citation Articles by Hajnal, A. Articles by Bello, N. T.

APPETITE, OBESITY, DIGESTION, AND METABOLISM

Altered taste sensitivity in obese, prediabetic OLETF rats lacking CCK-1 receptors

¹Department of Neural and Behavioral Sciences, The Pennsylvania State University, College of Medicine, Hershey; ²Department of Nutritional Sciences, The Pennsylvania State University, University Park, Pennsylvania

Submitted 10 June 2005 ; accepted in final form 26 July 2005

Otsuka Long-Evans Tokushima fatty (OLETF) rats lack the CCK-1 receptor, are hyperphagic, progressively become obese, and develop type-2 diabetes. We recently demonstrated an increased preference for both real and sham feeding of sucrose in this strain, suggesting altered orosensory sensitivity. To investigate taste functions, we used an automated gustometer with 10-s access to different concentrations of various sapid stimuli. Tests were repeated at 10 and 18 wk of age to assess the early and advanced stages of prediabetes, respectively. Compared with age-matched, nonmutant controls, the OLETF rats showed higher avidity for sucrose at both ages. This difference increased as a function of age and tastant concentration. An exaggerated response also occurred for saccharin, alanine, and fructose, but not for Polycose. Similarly, OLETF rats consumed monosodium-glutamate more at the lower concentrations compared with controls, an effect that age also accentuated. In contrast, there was no statistical strain or age differences in responses to NaCl, MgCl2, citric acid, quinine-HCl, and the trigeminal stimulus capsaicin. These findings demonstrate that compared with controls, OLETF rats differ in their gustatory functions with an overall augmented sensitivity for sweet that progresses during prediabetes. This effect explains their overconsumption of sweet solutions and may contribute to the overall hyperphagia and obesity in this strain.

overeating; dietary obesity; insulin resistance; sweet receptors; hedonic coding

This article has been cited by other articles:

				P. Kovacs and A. Hajnal Altered Pontine Taste Processing in a Rat Model of Obesity J Neurophysiol, October 1, 2008; 100(4): 2145 - 2157. [Abstract] [Full Text] [PDF]

				A. Hajnal, N. K. Acharya, P. S. Grigson, M. Covasa, and R. C. Twining Obese OLETF rats exhibit increased operant performance for palatable sucrose solutions and differential sensitivity to D2 receptor antagonism Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2007; 293(5): R1846 - R1854. [Abstract] [Full Text] [PDF]

				E. Anderzhanova, M. Covasa, and A. Hajnal Altered basal and stimulated accumbens dopamine release in obese OLETF rats as a function of age and diabetic status Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2007; 293(2): R603 - R611. [Abstract] [Full Text] [PDF]

				R. R. Gainetdinov Mesolimbic dopamine in obesity and diabetes Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2007; 293(2): R601 - R602. [Full Text] [PDF]

				B. C. De Jonghe, A. Hajnal, and M. Covasa Conditioned preference for sweet stimuli in OLETF rat: effects of food deprivation Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2007; 292(5): R1819 - R1827. [Abstract] [Full Text] [PDF]

				B. C. De Jonghe, A. Hajnal, and M. Covasa Decreased gastric mechanodetection, but preserved gastric emptying, in CCK-1 receptor-deficient OLETF rats Am J Physiol Gastrointest Liver Physiol, October 1, 2006; 291(4): G640 - G649. [Abstract] [Full Text] [PDF]