AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 289: R486-R494, 2005; doi:10.1152/ajpregu.00846.2004
0363-6119/05 $8.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (12)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Rossi, A. S.
Right arrow Articles by Rizkalla, S. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rossi, A. S.
Right arrow Articles by Rizkalla, S. W.

APPETITE, OBESITY, DIGESTION, AND METABOLISM

Dietary fish oil positively regulates plasma leptin and adiponectin levels in sucrose-fed, insulin-resistant rats

Andrea S. Rossi,1 Yolanda B. Lombardo,1 Jean-Marc Lacorte,2 Adriana G. Chicco,1 Christine Rouault,3,4 Gérard Slama,4 and Salwa W. Rizkalla3,4

1Department of Biochemistry, School of Biochemistry, University of Litoral, Santa Fe, Argentina; and 2Institut National de la Santé et de la Recherche Médicale (INSERM) U 505 and 3INSERM U 341, 4Department of Diabetes, Hotel Dieu, Hospital, Paris, France

Submitted 16 December 2004 ; accepted in final form 4 April 2005

Insulin resistance and adiposity induced by a long-term sucrose-rich diet (SRD) in rats could be reversed by fish oil (FO). Regulation of plasma leptin and adiponectin levels, as well as their gene expression, by FO might be implicated in these findings. This study was designed to evaluate the long-term regulation of leptin and adiponectin by dietary FO in a dietary model of insulin resistance induced by long-term SRD in rats and to determine their impact on adiposity and insulin sensitivity. Rats were randomized to consume a control diet (CD; n = 25) or an SRD (n = 50) for 7 mo. Subsequently, the SRD-fed rats were randomized to consume SRD+FO or to continue on SRD for an additional 2 mo. Long-term SRD induced overweight and decreased both plasma leptin and adiponectin levels without change in gene expression. Dyslipidemia, adiposity, and insulin resistance accompanied these modifications. Shifting the source of fat to FO for 2 mo increased plasma levels of both adipokines, reversed insulin resistance and dyslipidemia, and improved adiposity. These results were not associated with modifications in gene expression. These results suggest that increasing both adipokines by dietary FO might play an essential role in the normalization of insulin resistance and adiposity in dietary-induced, insulin-resistant models.

adipokines; insulin resistance; sucrose-rich diet


Address for reprint requests and other correspondence: Y. B. Lombardo, Dept. of Biochemistry, School of Biochemistry, Univ. of Litoral, Ciudad Universitaria, Paraje "El Pozo" C.C 242 (3000) Santa Fe, Argentina(E-mail: ylombard{at}fbcb.unl.edu.ar)




This article has been cited by other articles:


Home page
 Am. J. Clin. Nutr.Home page
M. Kratz, M. M Swarbrick, H. S Callahan, C. C Matthys, P. J Havel, and D. S Weigle
Effect of dietary n-3 polyunsaturated fatty acids on plasma total and high-molecular-weight adiponectin concentrations in overweight to moderately obese men and women
Am. J. Clinical Nutrition, February 1, 2008; 87(2): 347 - 353.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
M. Kabir, G. Skurnik, N. Naour, V. Pechtner, E. Meugnier, S. Rome, A. Quignard-Boulange, H. Vidal, G. Slama, K. Clement, et al.
Treatment for 2 mo with n 3 polyunsaturated fatty acids reduces adiposity and some atherogenic factors but does not improve insulin sensitivity in women with type 2 diabetes: a randomized controlled study
Am. J. Clinical Nutrition, December 1, 2007; 86(6): 1670 - 1679.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
M. Itoh, T. Suganami, N. Satoh, K. Tanimoto-Koyama, X. Yuan, M. Tanaka, H. Kawano, T. Yano, S. Aoe, M. Takeya, et al.
Increased Adiponectin Secretion by Highly Purified Eicosapentaenoic Acid in Rodent Models of Obesity and Human Obese Subjects
Arterioscler. Thromb. Vasc. Biol., September 1, 2007; 27(9): 1918 - 1925.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
V. Saraswathi, L. Gao, J. D. Morrow, A. Chait, K. D. Niswender, and A. H. Hasty
Fish Oil Increases Cholesterol Storage in White Adipose Tissue with Concomitant Decreases in Inflammation, Hepatic Steatosis, and Atherosclerosis in Mice
J. Nutr., July 1, 2007; 137(7): 1776 - 1782.
[Abstract] [Full Text] [PDF]

Home page
 Arch. Dis. Child. Fetal Neonatal Ed.Home page
T. Siahanidou, H. Mandyla, G.-P. Papassotiriou, I. Papassotiriou, and G. Chrousos
Circulating levels of adiponectin in preterm infants
Arch. Dis. Child. Fetal Neonatal Ed., July 1, 2007; 92(4): F286 - F290.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
N. Sharma, I. C. Okere, M. K. Duda, D. J. Chess, K. M. O'Shea, and W. C. Stanley
Potential impact of carbohydrate and fat intake on pathological left ventricular hypertrophy
Cardiovasc Res, January 15, 2007; 73(2): 257 - 268.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
P. B. Persson
From clinical insights to new therapies
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2006; 290(1): R124 - R125.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2005 by the American Physiological Society.