| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
APPETITE, OBESITY, DIGESTION, AND METABOLISM
1Department of Foods and Nutrition, Dawson Hall, University of Georgia, Athens; and 2Department of Biology and Center for Behavioral Neuroscience, Georgia State University, Atlanta, Georgia
Submitted 21 December 2004 ; accepted in final form 22 February 2005
Leptin increases sympathetic nervous system (SNS) activity in brown adipose tissue and renal nerves. Experiments described here tested whether SNS innervation is required for peripheral, physiological concentrations of leptin to reduce body fat. In experiment 1, one epididymal (EPI) fat pad was sympathectomized by local injection of 6-hydroxydopamine (6OHDA) in C57BL/6 mice that were then infused for 13 days with PBS or 10 µg leptin/day from an intraperitoneal miniosmotic pump. Surprisingly, EPI denervation increased total body fat of PBS-infused mice but leptin decreased the size of both injected and noninjected EPI pads in 6OHDA mice. Experiment 2 was identical except for the use of male Sprague-Dawley rats that were infused with 50 µg leptin/day. Leptin had little effect on EPI weight or norepinephrine (NE) content, but denervation of one EPI pad decreased the effect of leptin on intact EPI, inguinal and retroperitoneal (RP) fat and increased the size of the mesenteric fat pad. Experiment 3 included groups in which either one EPI or one RP pad was denervated. RP denervation reduced RP NE content but did not prevent a leptin-induced reduction in fat pad mass. Therefore, the SNS is not required for low doses of leptin to reduce body fat. EPI denervation significantly increased adipocyte number in contralateral EPI and RP fat pads and this was prevented by leptin. These changes in intact pads of rats with one denervated fat pad imply communication between fat depots and suggest that both leptin and the SNS regulate the size of individual depots.
peripheral leptin infusion; norepinephrine; body weight
This article has been cited by other articles:
|
|
 |
|
  T. J. Bartness and C. K. Song Thematic review series: Adipocyte Biology. Sympathetic and sensory innervation of white adipose tissue J. Lipid Res., August 1, 2007; 48(8): 1655 - 1672. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Giordano, C. Kay Song, R. R. Bowers, J. Christopher Ehlen, A. Frontini, S. Cinti, and T. J. Bartness Reply to Kreier and Buijs: no sympathy for the claim of parasympathetic innervation of white adipose tissue Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2007; 293(1): R550 - R552. [Full Text] [PDF]
|
|
|
|
|
|
D. M. Penn, L. C. Jordan, E. W. Kelso, J. E. Davenport, and R. B. S. Harris Effects of central or peripheral leptin administration on norepinephrine turnover in defined fat depots Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2006; 291(6): R1613 - R1621. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. T. Foster and T. J. Bartness Sympathetic but not sensory denervation stimulates white adipocyte proliferation Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2006; 291(6): R1630 - R1637. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Giordano, C. K. Song, R. R. Bowers, J. C. Ehlen, A. Frontini, S. Cinti, and T. J. Bartness White adipose tissue lacks significant vagal innervation and immunohistochemical evidence of parasympathetic innervation Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2006; 291(5): R1243 - R1255. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Wagoner, D. B. Hausman, and R. B. S. Harris Direct and indirect effects of leptin on preadipocyte proliferation and differentiation Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2006; 290(6): R1557 - R1564. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
