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Am J Physiol Regul Integr Comp Physiol 287: R1009-R1011, 2004; doi:10.1152/classicessays.00007.2004
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EDITORIAL FOCUS

ESSAYS ON APS CLASSIC PAPERS

The pioneering use of systems analysis to study cardiac output regulation

Department of Physiology and Biophysics, School of Medicine, University of Mississippi Medical Center, Jackson, Mississippi 39216

ABSTRACT

This essay examines the historical significance of an APS classic paper that is freely available online:

Guyton AC, Lindsey AW, and Kaufmann BN. Effect of mean circulatory filling pressure and other peripheral circulatory factors on cardiac output. Am J Physiol 180: 463-468, 1955 (http://ajplegacy.physiology.org/cgi/reprint/180/3/463).

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