HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 286/6/R1043    most recent 00582.2003v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (6) Citing Articles via Google Scholar Google Scholar Articles by Curtis, K. S. Articles by Contreras, R. J. Search for Related Content PubMed PubMed Citation Articles by Curtis, K. S. Articles by Contreras, R. J.

THIRST AND VOLUME, ELECTROLYTE HOMEOSTASIS

Gestational and early postnatal dietary NaCl levels affect NaCl intake, but not stimulated water intake, by adult rats

Department of Psychology and Program in Neuroscience, The Florida State University, Tallahassee, Florida 32306-1270

Submitted 7 October 2003 ; accepted in final form 31 January 2004

We examined body fluid regulation by weanling (21–25 days) and adult (>60 days) male rats that were offspring of dams fed chow containing either 0.1, 1, or 3% NaCl throughout gestation and lactation. Weanling rats were maintained on the test diets until postnatal day 30 and on standard 1% NaCl chow thereafter. Ad libitum water intake by weanlings was highest in those fed 3% NaCl and lowest in those fed 0.1% NaCl. Adult rats maintained on standard NaCl chow consumed similar amounts of water after overnight water deprivation or intravenous hypertonic NaCl (HS) infusion regardless of early NaCl condition. Moreover, baseline and HS-stimulated plasma Na⁺ concentrations also were similar for the three groups. Nonetheless, adult rats in the early 3% NaCl group consumed more of 0.5 M NaCl after 10 days of dietary Na⁺ deprivation than did rats in either the 1% or 0.1% NaCl group. Interestingly, whether NaCl was consumed in a concentrated solution in short-term, two-bottle tests after dietary Na⁺ deprivation or in chow during ad libitum feeding, adult rats in the 3% NaCl group drank less water for each unit of NaCl consumed, whereas rats in the 0.1% NaCl group drank more water for each unit of NaCl consumed. Thus gestational and early postnatal dietary NaCl levels do not affect stimulated water intake or long-term body fluid regulation. Together with our previous studies, these results suggest that persistent changes in NaCl intake and in water intake associated with NaCl ingestion reflect short-term behavioral effects that may be attributable to differences in NaCl taste processing.

hypernatremia; thirst; development; taste; hypertension

This article has been cited by other articles:

				S. M. McBride, B. Culver, and F. W. Flynn Dietary sodium manipulation during critical periods in development sensitize adult offspring to amphetamines Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2008; 295(3): R899 - R905. [Abstract] [Full Text] [PDF]

				A. Shirazki, Z. Weintraub, D. Reich, E. Gershon, and M. Leshem Lowest neonatal serum sodium predicts sodium intake in low birth weight children Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2007; 292(4): R1683 - R1689. [Abstract] [Full Text] [PDF]

				S. M. McBride, B. Culver, and F. W. Flynn Prenatal and early postnatal dietary sodium restriction sensitizes the adult rat to amphetamines Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2006; 291(4): R1192 - R1199. [Abstract] [Full Text] [PDF]