AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 286: R608-R623, 2004; doi:10.1152/ajpregu.00538.2003
0363-6119/04 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (79)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Höpfl, G.
Right arrow Articles by Gassmann, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Höpfl, G.
Right arrow Articles by Gassmann, M.

INVITED REVIEW

HIFs and tumors—causes and consequences

Gisele Höpfl, Omolara Ogunshola, and Max Gassmann

Institute of Veterinary Physiology, University of Zürich, CH-8057 Zürich, Switzerland

For most organisms oxygen is essential for life. When oxygen levels drop below those required to maintain the minimum physiological oxygen requirement of an organism or tissue it is termed hypoxia. To counteract possible deleterious effects of such a state, an immediate molecular response is initiated causing adaptation responses aimed at cell survival. This response is mediated by the hypoxia-inducible factor-1 (HIF-1), which is a heterodimer consisting of an {alpha}- and a {beta}-subunit. HIF-1{alpha} protein is stabilized under hypoxic conditions and therefore confers selectivity to this response. Hypoxia is characteristic of tumors, mainly because of impaired blood supply resulting from abnormal growth. Over the past few years enormous progress has been made in the attempt to understand how the activation of the physiological response to hypoxia influences neoplastic growth. In this review some aspects of HIF-1 pathway activation in tumors and the consequences for pathophysiology and treatment of neoplasia are discussed.

hypoxia; cancer; oxygen-sensing; oncogenes; vasculature


Address for reprint requests and other correspondence: M. Gassmann, Institute of Veterinary Physiology, Univ. of Zürich, Winterthurerstrasse 260, CH-8057 Zürich, Switzerland (E-mail: maxg{at}access.unizh.ch).




This article has been cited by other articles:


Home page
 Mol Cancer ResHome page
M. Elser, L. Borsig, P. O. Hassa, S. Erener, S. Messner, T. Valovka, S. Keller, M. Gassmann, and M. O. Hottiger
Poly(ADP-Ribose) Polymerase 1 Promotes Tumor Cell Survival by Coactivating Hypoxia-Inducible Factor-1-Dependent Gene Expression
Mol. Cancer Res., February 1, 2008; 6(2): 282 - 290.
[Abstract] [Full Text] [PDF]

Home page
 Mol Cancer ResHome page
H.-J. Kim, H. Chung, Y.-G. Yoo, H. Kim, J.-Y. Lee, M.-O. Lee, and G. Kong
Inhibitor of DNA Binding 1 Activates Vascular Endothelial Growth Factor through Enhancing the Stability and Activity of Hypoxia-Inducible Factor-1{alpha}
Mol. Cancer Res., April 1, 2007; 5(4): 321 - 329.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
K. Heinicke, O. Baum, O. O. Ogunshola, J. Vogel, T. Stallmach, D. P. Wolfer, S. Keller, K. Weber, P. D. Wagner, M. Gassmann, et al.
Excessive erythrocytosis in adult mice overexpressing erythropoietin leads to hepatic, renal, neuronal, and muscular degeneration
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2006; 291(4): R947 - R956.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
J. Fandrey, T. A. Gorr, and M. Gassmann
Regulating cellular oxygen sensing by hydroxylation
Cardiovasc Res, September 1, 2006; 71(4): 642 - 651.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
A. Hubert, S. Paris, J.-P. Piret, N. Ninane, M. Raes, and C. Michiels
Casein kinase 2 inhibition decreases hypoxia-inducible factor-1 activity under hypoxia through elevated p53 protein level
J. Cell Sci., August 15, 2006; 119(16): 3351 - 3362.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
P. Trayhurn, C. Bing, and I. S. Wood
Adipose Tissue and Adipokines--Energy Regulation from the Human Perspective
J. Nutr., July 1, 2006; 136(7): 1935S - 1939S.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
L. Schaffer, J. Vogel, C. Breymann, M. Gassmann, and H. H. Marti
Preserved placental oxygenation and development during severe systemic hypoxia
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2006; 290(3): R844 - R851.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
O. O. Ogunshola, V. Djonov, R. Staudt, J. Vogel, and M. Gassmann
Chronic excessive erythrocytosis induces endothelial activation and damage in mouse brain
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2006; 290(3): R678 - R684.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
N. Tajima, K. Schonherr, S. Niedling, M. Kaatz, H. Kanno, R. Schonherr, and S. H. Heinemann
Ca2+-activated K+ channels in human melanoma cells are up-regulated by hypoxia involving hypoxia-inducible factor-1{alpha} and the von Hippel-Lindau protein
J. Physiol., March 1, 2006; 571(2): 349 - 359.
[Abstract] [Full Text] [PDF]

Home page
 Mol Cancer ResHome page
R. Cairns, I. Papandreou, and N. Denko
Overcoming Physiologic Barriers to Cancer Treatment by Molecularly Targeting the Tumor Microenvironment
Mol. Cancer Res., February 1, 2006; 4(2): 61 - 70.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S. Amir, R. Wang, H. Matzkin, J. W. Simons, and N. J. Mabjeesh
MSF-A Interacts with Hypoxia-Inducible Factor-1{alpha} and Augments Hypoxia-Inducible Factor Transcriptional Activation to Affect Tumorigenicity and Angiogenesis
Cancer Res., January 15, 2006; 66(2): 856 - 866.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
I. Csiki, K. Yanagisawa, N. Haruki, S. Nadaf, J. D. Morrow, D. H. Johnson, and D. P. Carbone
Thioredoxin-1 Modulates Transcription of Cyclooxygenase-2 via Hypoxia-Inducible Factor-1{alpha} in Non-Small Cell Lung Cancer
Cancer Res., January 1, 2006; 66(1): 143 - 150.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
G. J. Kelloff, K. A. Krohn, S. M. Larson, R. Weissleder, D. A. Mankoff, J. M. Hoffman, J. M. Link, K. Z. Guyton, W. C. Eckelman, H. I. Scher, et al.
The Progress and Promise of Molecular Imaging Probes in Oncologic Drug Development
Clin. Cancer Res., November 15, 2005; 11(22): 7967 - 7985.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
M. Edward, C. Gillan, D. Micha, and R.H. Tammi
Tumour regulation of fibroblast hyaluronan expression: a mechanism to facilitate tumour growth and invasion
Carcinogenesis, July 1, 2005; 26(7): 1215 - 1223.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S. Frede, P. Freitag, T. Otto, C. Heilmaier, and J. Fandrey
The Proinflammatory Cytokine Interleukin 1{beta} and Hypoxia Cooperatively Induce the Expression of Adrenomedullin in Ovarian Carcinoma Cells through Hypoxia Inducible Factor 1 Activation
Cancer Res., June 1, 2005; 65(11): 4690 - 4697.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
K. L. Covello, M. C. Simon, and B. Keith
Targeted Replacement of Hypoxia-Inducible Factor-1{alpha} by a Hypoxia-Inducible Factor-2{alpha} Knock-in Allele Promotes Tumor Growth
Cancer Res., March 15, 2005; 65(6): 2277 - 2286.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
L. K. Kairaitis, Y. Wang, M. Gassmann, Y.-C. Tay, and D. C. H. Harris
HIF-1{alpha} expression follows microvascular loss in advanced murine adriamycin nephrosis
Am J Physiol Renal Physiol, January 1, 2005; 288(1): F198 - F206.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
Y. Ma, P. Freitag, J. Zhou, B. Brune, S. Frede, and J. Fandrey
Thyroid hormone induces erythropoietin gene expression through augmented accumulation of hypoxia-inducible factor-1
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2004; 287(3): R600 - R607.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
C. Grimm, A. Wenzel, D. Stanescu, M. Samardzija, S. Hotop, M. Groszer, M. Naash, M. Gassmann, and C. Reme
Constitutive Overexpression of Human Erythropoietin Protects the Mouse Retina against Induced But Not Inherited Retinal Degeneration
J. Neurosci., June 23, 2004; 24(25): 5651 - 5658.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2004 by the American Physiological Society.