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NEUROHUMORAL CONTROL OF CIRCULATION AND HYPERTENSION
Département de Physiologie et Pharmacologie Clinique, Centre National de la Recherche Scientifique Formation de Recherche en Evolution 2678, Faculté de Pharmacie, Université Claude Bernard Lyon 1, Lyon 69373, France
Submitted 28 February 2003 ; accepted in final form 5 June 2003
The role of arterial baroreceptors in controlling arterial pressure (AP)
variability through changes in sympathetic nerve activity was examined in
conscious rats. AP and renal sympathetic nerve activity (RSNA) were measured
continuously during 1-h periods in freely behaving rats that had been
subjected to sinoaortic baroreceptor denervation (SAD) or a sham operation 2
wk before study (n = 10 in each group). Fast Fourier transform
analysis revealed that chronic SAD did not alter high-frequency (0.75-5 Hz)
respiratory-related oscillations of mean AP (MAP) and RSNA, decreased by
50% spectral power of both variables in the midfrequency band (MF,
0.27-0.74 Hz) containing the so-called Mayer waves, and induced an eightfold
increase in MAP power without altering RSNA power in the low-frequency band
(0.005-0.27 Hz). In both groups of rats, coherence between RSNA and MAP was
maximal in the MF band and was usually weak at lower frequencies. In SAD rats,
the transfer function from RSNA to MAP showed the characteristics of a
second-order low-pass filter containing a fixed time delay (0.5 s). These
results indicate that arterial baroreceptors are not involved in production of
respiratory-related oscillations of RSNA but play a major role in the genesis
of synchronous oscillations of MAP and RSNA at the frequency of Mayer waves.
The weak coupling between slow fluctuations of RSNA and MAP in sham-operated
and SAD rats points to the interference of noise sources unrelated to RSNA
affecting MAP and of noise sources unrelated to MAP affecting RSNA.
Mayer waves; renal sympathetic nerve activity; sinoaortic baroreceptor denervation; spectral analysis; transfer function
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