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This Article Full Text Full Text (PDF) All Versions of this Article: 285/2/R463    most recent 00153.2003v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (11) Citing Articles via Google Scholar Google Scholar Articles by Aker, S. Articles by Schulz, R. Search for Related Content PubMed PubMed Citation Articles by Aker, S. Articles by Schulz, R.

INFLAMMATION, CYTOKINES, AND TEMPERATURE REGULATION

Serum but not myocardial TNF- concentration is increased in pacing-induced heart failure in rabbits

Institute of Pathophysiology, University of Essen Medical School, 45122 Essen, Germany

Submitted 26 March 2003 ; accepted in final form 8 May 2003

In animals and patients with severe heart failure (HF), the serum tumor necrosis factor- (TNF-) concentration is increased. It is, however, still controversial whether or not such increased serum TNF- originates from the heart itself or is of peripheral origin secondary to gastrointestinal congestion and increased endotoxin concentration. We therefore now examined TNF- in serum, myocardium, and liver of sham-operated and HF rabbits. In nine rabbits in which HF was induced by left ventricular (LV) pacing at 400 beats/min for 3 wk, LV end-diastolic diameter was increased and systolic shortening fraction (9.4 ± 1.0 vs. 28.5 ± 1.3%, echocardiography, P < 0.05) was reduced. Serum TNF- was higher in HF than in sham-operated rabbits (240 ± 24 vs. 150 ± 22 U/ml, WEHI-cell assay, P < 0.05). In the heart, TNF- was located mainly in the vascular endothelium (immunohistochemistry), and TNF- protein (920 ± 160 vs. 900 ± 95 U/g) did not differ between groups. In the liver of HF rabbits, hepatocytes expressed TNF-, and TNF- protein was increased compared with sham-operated rabbits (2,390 ± 310 vs. 1,220 ± 135 U/g, P < 0.05) and correlated to the number of hepatic leukocytes (r = 0.85) and serum TNF- (r = 0.69). The intestinal endotoxin concentration was 24.5 ± 1.2 vs. 17.0 ± 3.1 endotoxin units/g wet wt (P < 0.05) in HF compared with sham-operated rabbits. In this HF model, serum but not myocardial TNF- is increased. The increased serum TNF- originates from peripheral sources.

liver; inflammation

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