AJP - Regu Watch the video to learn how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 284: R983-R989, 2003. First published January 9, 2003; doi:10.1152/ajpregu.00761.2001
0363-6119/03 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
284/4/R983    most recent
00761.2001v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (7)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Pamidimukkala, J.
Right arrow Articles by Hay, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pamidimukkala, J.
Right arrow Articles by Hay, M.
Vol. 284, Issue 4, R983-R989, April 2003

Estrogen modulation of baroreflex function in conscious mice

Jaya Pamidimukkala1, Julia A. Taylor2, Wade V. Welshons2, Dennis B. Lubahn3,4, and Meredith Hay1,2

1 Dalton Cardiovascular Research Center, 2 Department of Veterinary Biomedical Sciences, 3 Department of Biochemistry and Child Health, 4 Center for Phytonutrient and Phytochemical Studies, University of Missouri, Columbia, Missouri 65211

It has been suggested that estrogen modulates baroreflex regulation of autonomic function. The present study evaluated the effects of estrogen on baroreflex regulation of heart rate in response to changes in blood pressure with phenylephrine (PE), ANG II, and sodium nitroprusside (SNP) in a conscious mouse model. Males and ovariectomized females with (OvxE+) and without (OvxE-) estradiol replacement chronically implanted with arterial and venous catheters were used in these studies. The slope of the baroreflex bradycardic responses to PE was significantly facilitated in OvxE+ females (-7.65 ± 1.37) compared with OvxE- females (-4.5 ± 0.4). Likewise, the slope of the baroreflex bradycardic responses to ANG II was significantly facilitated in OvxE+ females (-7.97 ± 1.06) compared with OvxE- females (-4.8 ± 1.6). Reflex tachycardic responses to SNP were comparable in all the groups. Finally, in male mice, the slope of ANG II-induced baroreflex bradycardia (-5.17 ± 0.95) was significantly less than that induced by PE (-8.50 ± 0.92), but this ANG II-mediated attenuation of reflex bradycardia was not observed in the female mice. These data support the hypothesis that estrogen facilitates baroreflex function in female mice and suggest that ANG II-mediated acute blunting of baroreflex regulation of heart rate may be sex dependent.

gender differences; autonomic regulation; cardiac baroreflexes


This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
H. Girouard, A. Lessard, C. Capone, T. A. Milner, and C. Iadecola
The neurovascular dysfunction induced by angiotensin II in the mouse neocortex is sexually dimorphic
Am J Physiol Heart Circ Physiol, January 1, 2008; 294(1): H156 - H163.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
E. G. Krause, K. S. Curtis, J. P. Markle, and R. J. Contreras
Oestrogen affects the cardiovascular and central responses to isoproterenol of female rats
J. Physiol., July 1, 2007; 582(1): 435 - 447.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. M. Wenner, A. V. Prettyman, R. E. Maser, and W. B. Farquhar
Preserved autonomic function in amenorrheic athletes
J Appl Physiol, August 1, 2006; 101(2): 590 - 597.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
B. Xue, J. Pamidimukkala, and M. Hay
Sex differences in the development of angiotensin II-induced hypertension in conscious mice
Am J Physiol Heart Circ Physiol, May 1, 2005; 288(5): H2177 - H2184.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. Pamidimukkala, B. Xue, L. G. Newton, D. B. Lubahn, and M. Hay
Estrogen receptor-{alpha} mediates estrogen facilitation of baroreflex heart rate responses in conscious mice
Am J Physiol Heart Circ Physiol, March 1, 2005; 288(3): H1063 - H1070.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
P. J. Harvey, B. L. Morris, J. A. Miller, and J. S. Floras
Estradiol Induces Discordant Angiotensin and Blood Pressure Responses to Orthostasis in Healthy Postmenopausal Women
Hypertension, March 1, 2005; 45(3): 399 - 405.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online