| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 University of Wisconsin-Madison, Department of Obstetrics and Gynecology, Perinatal Research Laboratories and the 2 Department of Pediatrics and 4 Animal Sciences, Madison, Wisconsin 53715; and 3 Center for Perinatal Biology, Department of Pharmacology and Physiology, Loma Linda University School of Medicine, Loma Linda, California 92350
The last 10 years has seen a dramatic increase in our understanding of the mechanisms underlying the pregnancy-specific adaptation in cardiovascular function in general and the dramatic changes that occur in uterine artery endothelium in particular to support the growing fetus. The importance of these changes is clear from a number of studies linking restriction of uterine blood flow (UBF) and/or endothelial dysfunction and clinical conditions such as intrauterine growth retardation (IUGR) and/or preeclampsia in both humans and animal models; these topics are covered only briefly here. The recent developments that prompts this review are twofold. The first is advances in an understanding of the cell signaling processes that regulate endothelial nitric oxide synthase (eNOS) in particular (Govers R and Rabelink TJ. Am J Physiol Renal Physiol 280: F193-F206, 2001). The second is the emerging picture that uterine artery (UA) endothelial cell production of nitric oxide (NO) as well as prostacyclin (PGI2) may be as much a consequence of cellular reprogramming at the level of cell signaling as due to tonic stimuli inducing changes in the level of expression of eNOS or the enzymes of the PGI2 biosynthetic pathway (cPLA2, COX-1, PGIS). In reviewing just how we came to this conclusion and outlining the implications of such a finding, we draw mostly on data from ovine or human studies, with reference to other species only where directly relevant.
nitric oxide; prostacyclin; calcium; kinases; programming
This article has been cited by other articles:
|
|
 |
|
  Y. Lu, H. Zhang, N. Gokina, M. Mandala, O. Sato, M. Ikebe, G. Osol, and S. A. Fisher Uterine artery myosin phosphatase isoform switching and increased sensitivity to SNP in a rat L-NAME model of hypertension of pregnancy Am J Physiol Cell Physiol, February 1, 2008; 294(2): C564 - C571. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Zhang and L. Zhang Role of Protein Kinase C Isozymes in the Regulation of alpha1-Adrenergic Receptor-Mediated Contractions in Ovine Uterine Arteries Biol Reprod, January 1, 2008; 78(1): 35 - 42. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Telezhkin, T. Goecks, A. D. Bonev, G. Osol, and N. I. Gokina Decreased function of voltage-gated potassium channels contributes to augmented myogenic tone of uterine arteries in late pregnancy Am J Physiol Heart Circ Physiol, January 1, 2008; 294(1): H272 - H284. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. N. Van Vliet and L. L. Chafe Maternal Endothelial Nitric Oxide Synthase Genotype Influences Offspring Blood Pressure and Activity in Mice Hypertension, March 1, 2007; 49(3): 556 - 562. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Zhang, D. Xiao, L. D. Longo, and L. Zhang Regulation of {alpha}1-adrenoceptor-mediated contractions of uterine arteries by PKC: effect of pregnancy Am J Physiol Heart Circ Physiol, November 1, 2006; 291(5): H2282 - H2289. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Xiao, X. Huang, L. D. Longo, W. J. Pearce, and L. Zhang Regulation of baseline Ca2+ sensitivity in permeabilized uterine arteries: effect of pregnancy Am J Physiol Heart Circ Physiol, July 1, 2006; 291(1): H413 - H420. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Xiao, J. N. Buchholz, and L. Zhang Pregnancy attenuates uterine artery pressure-dependent vascular tone: role of PKC/ERK pathway Am J Physiol Heart Circ Physiol, June 1, 2006; 290(6): H2337 - H2343. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. I. Gokina and T. Goecks Upregulation of endothelial cell Ca2+ signaling contributes to pregnancy-enhanced vasodilation of rat uteroplacental arteries Am J Physiol Heart Circ Physiol, May 1, 2006; 290(5): H2124 - H2135. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. P. Reynolds, J. S. Caton, D. A. Redmer, A. T. Grazul-Bilska, K. A. Vonnahme, P. P. Borowicz, J. S. Luther, J. M. Wallace, G. Wu, and T. E. Spencer Evidence for altered placental blood flow and vascularity in compromised pregnancies J. Physiol., April 1, 2006; 572(1): 51 - 58. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Cale and I. M. Bird Dissociation of endothelial nitric oxide synthase phosphorylation and activity in uterine artery endothelial cells Am J Physiol Heart Circ Physiol, April 1, 2006; 290(4): H1433 - H1445. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. W.H. van der Heijden, Y. P.G. Essers, M. E.A. Spaanderman, J. G.R. De Mey, G. J.J.M. van Eys, and L. L.H. Peeters Uterine Artery Remodeling in Pseudopregnancy Is Comparable to That in Early Pregnancy Biol Reprod, December 1, 2005; 73(6): 1289 - 1293. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Longo, V. Jain, Y. P. Vedernikov, R. Bukowski, R. E. Garfield, G. D. Hankins, G. D. Anderson, and G. R. Saade Fetal origins of adult vascular dysfunction in mice lacking endothelial nitric oxide synthase Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2005; 288(5): R1114 - R1121. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Cale, S. C. Tsoi, M. Toppe, M. A. Grummer, M. Ochiai, R. R. Magness, and I. M. Bird Molecular Cloning of Ovine Endothelial Nitric Oxide Synthase and Expression in COS-7 Cells Reproductive Sciences, April 1, 2005; 12(3): 156 - 168. [Abstract] [PDF]
|
|
|
|
|
|
D. G. Hemmings, S. Veerareddy, P. N. Baker, and S. T. Davidge Increased Myogenic Responses in Uterine but not Mesenteric Arteries from Pregnant Offspring of Diet-Restricted Rat Dams Biol Reprod, April 1, 2005; 72(4): 997 - 1003. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. G. R. De Mey, P. M. Schiffers, R. H. P. Hilgers, and M. M. W. Sanders Toward functional genomics of flow-induced outward remodeling of resistance arteries Am J Physiol Heart Circ Physiol, March 1, 2005; 288(3): H1022 - H1027. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Meziani, B. Van Overloop, F. Schneider, and A. Gairard Parathyroid Hormone-Related Protein-induced Relaxation of Rat Uterine Arteries: Influence of the Endothelium During Gestation Reproductive Sciences, January 1, 2005; 12(1): 14 - 19. [Abstract] [PDF]
|
|
|
|
|
|
F.-X. Yi, R. R. Magness, and I. M. Bird Simultaneous imaging of [Ca2+]i and intracellular NO production in freshly isolated uterine artery endothelial cells: effects of ovarian cycle and pregnancy Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2005; 288(1): R140 - R148. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Xiao and L. Zhang Adaptation of uterine artery thick- and thin-filament regulatory pathways to pregnancy Am J Physiol Heart Circ Physiol, January 1, 2005; 288(1): H142 - H148. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Kwon, S. P. Ford, F. W. Bazer, T. E. Spencer, P. W. Nathanielsz, M. J. Nijland, B. W. Hess, and G. Wu Maternal Nutrient Restriction Reduces Concentrations of Amino Acids and Polyamines in Ovine Maternal and Fetal Plasma and Fetal Fluids Biol Reprod, September 1, 2004; 71(3): 901 - 908. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. W. H. van der Heijden, Y. P. G. Essers, L. H. J. Simkens, Q. G. A. Teunissen, L. L. H. Peeters, J. G. R. De Mey, and G. J. J. M. van Eys Aging Blunts Remodeling of the Uterine Artery During Murine Pregnancy Reproductive Sciences, July 1, 2004; 11(5): 304 - 310. [Abstract] [PDF]
|
|
|
|
|
|
J. M. Orshal and R. A. Khalil Interleukin-6 impairs endothelium-dependent NO-cGMP-mediated relaxation and enhances contraction in systemic vessels of pregnant rats Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2004; 286(6): R1013 - R1023. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Luksha, H. Nisell, and K. Kublickiene The mechanism of EDHF-mediated responses in subcutaneous small arteries from healthy pregnant women Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2004; 286(6): R1102 - R1109. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Xiao and L. Zhang Calcium Homeostasis and Contraction of the Uterine Artery: Effect of Pregnancy and Chronic Hypoxia Biol Reprod, April 1, 2004; 70(4): 1171 - 1177. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Kwon, G. Wu, C. J. Meininger, F. W. Bazer, and T. E. Spencer Developmental Changes in Nitric Oxide Synthesis in the Ovine Placenta Biol Reprod, March 1, 2004; 70(3): 679 - 686. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Orshal and R. A. Khalil Reduced Endothelial NO-cGMP-Mediated Vascular Relaxation and Hypertension in IL-6-Infused Pregnant Rats Hypertension, February 1, 2004; 43(2): 434 - 444. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
