AJP - Regu AJP: Gastrointestinal and Liver Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 284: R116-R124, 2003. First published September 12, 2002; doi:10.1152/ajpregu.00336.2002
0363-6119/03 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
284/1/R116    most recent
00336.2002v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (8)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kopp, U. C.
Right arrow Articles by Smith, L. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kopp, U. C.
Right arrow Articles by Smith, L. A.
Vol. 284, Issue 1, R116-R124, January 2003

Impaired responsiveness of renal mechanosensory nerves in heart failure: role of endogenous angiotensin

Ulla C. Kopp, Michael Z. Cicha, and Lori A. Smith

Departments of Internal Medicine and Pharmacology, Department of Veterans Affairs Medical Center, and University of Iowa Roy J. and Lucille Carver College of Medicine, Iowa City, Iowa 52242

Increasing renal pelvic pressure results in PGE2-mediated release of substance P. Substance P increases afferent renal nerve activity (ARNA), which leads to a reflex increase in urinary sodium excretion (UNaV). Endogenous ANG II modulates the responsiveness of renal mechanosensory nerves. The ARNA and UNaV responses are suppressed by low- and enhanced by high-sodium diet. We examined whether the ARNA responses are altered in rats with congestive heart failure (CHF), a condition characterized by increased ANG II and sodium retention. The ARNA responses to increasing renal pelvic pressure <= 7.5 mmHg were suppressed in CHF vs. sham-CHF rats fed normal sodium diet. In CHF rats, increasing renal pelvic pressure 2.5 and 7.5 mmHg increased ARNA 0 ± 1 and 13 ± 2% (P < 0.01) before and 9 ± 1 (P < 0.01) and 19 ± 1% (P < 0.01) during renal pelvic perfusion with losartan. Losartan had no effect on the ARNA responses in sham-CHF rats. In isolated renal pelvises from CHF rats, PGE2 increased substance P release from 11 ± 2 to 15 ± 3 pg/min (not significant) without and from 16 ± 2 to 30 ± 4 pg/min (P < 0.01) with losartan in the incubation bath. Losartan had no effect on PGE2-mediated substance P release in sham-CHF rats. In conclusion, the responsiveness of renal mechanosensory nerves is impaired in CHF rats due to ANG II inhibiting PGE2-mediated release of substance P from renal pelvic nerves.

substance P; prostaglandins; sodium retention; AT1 receptors; losartan


This article has been cited by other articles:


Home page
 HypertensionHome page
M.-C. Ma, H.-S. Huang, Y.-S. Chen, and S.-H. Lee
Mechanosensitive N-Methyl-D-Aspartate Receptors Contribute to Sensory Activation in the Rat Renal Pelvis
Hypertension, November 1, 2008; 52(5): 938 - 944.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
U. C. Kopp, M. Z. Cicha, and M. A. Yorek
Impaired responsiveness of renal sensory nerves in streptozotocin-treated rats and obese Zucker diabetic fatty rats: role of angiotensin
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2008; 294(3): R858 - R866.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
N.-H. Feng, H.-H. Lee, J.-C. Shiang, and M.-C. Ma
Transient receptor potential vanilloid type 1 channels act as mechanoreceptors and cause substance P release and sensory activation in rat kidneys
Am J Physiol Renal Physiol, February 1, 2008; 294(2): F316 - F325.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
U. C. Kopp, M. Z. Cicha, L. A. Smith, J. Mulder, and T. Hokfelt
Renal sympathetic nerve activity modulates afferent renal nerve activity by PGE2-dependent activation of {alpha}1- and {alpha}2-adrenoceptors on renal sensory nerve fibers
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2007; 293(4): R1561 - R1572.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
U. C. Kopp, M. Z. Cicha, K. Nakamura, R. M. Nusing, L. A. Smith, and T. Hokfelt
Activation of EP4 receptors contributes to prostaglandin E2-mediated stimulation of renal sensory nerves
Am J Physiol Renal Physiol, December 1, 2004; 287(6): F1269 - F1282.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
U. C. Kopp and M. Z. Cicha
Impaired substance P release from renal sensory nerves in SHR involves a pertussis toxin-sensitive mechanism
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2004; 286(2): R326 - R333.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
O. Grisk and R. Rettig
Interactions between the sympathetic nervous system and the kidneys in arterial hypertension
Cardiovasc Res, February 1, 2004; 61(2): 238 - 246.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
U. C. Kopp, M. Z. Cicha, and L. A. Smith
Angiotensin blocks substance P release from renal sensory nerves by inhibiting PGE2-mediated activation of cAMP
Am J Physiol Renal Physiol, September 1, 2003; 285(3): F472 - F483.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online