AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 283: R964-R971, 2002. First published June 13, 2002; doi:10.1152/ajpregu.00629.2001
0363-6119/02 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
283/4/R964    most recent
00629.2001v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (8)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Leung, J. C.
Right arrow Articles by Silverstein, D. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Leung, J. C.
Right arrow Articles by Silverstein, D. M.
Vol. 283, Issue 4, R964-R971, October 2002

Expression and developmental regulation of the NMDA receptor subunits in the kidney and cardiovascular system

Jocelyn C. Leung1, Brett R. Travis2, Jill W. Verlander3, Satinder K. Sandhu4, Song-Gui Yang4, Arnold H. Zea5, I. David Weiner3,6, and Douglas M. Silverstein2

Department of Pediatrics, Divisions of 1 Neonatology, 2 Nephrology, and 4 Cardiology and 5 Departments of Pediatrics and Microbiology and the Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112; and 3 Department of Medicine, 6 Veterans Administration Medical Center, University of Florida, Gainesville, Florida 32611

Antagonists to the N-methyl-D-aspartate (NMDA) receptor bind to various extraneuronal tissues. We therefore assessed the expression of the main NMDA subunit, NR1, in various tissues. We demonstrate that NR1 appears to be most abundant in the rat kidney and heart. NR1 is present in total rat kidney, cortex, and medulla. Of the NR2 subunits, only the NR2C subunit protein is present in the kidney. The abundance of the NR1 subunit protein increases with kidney development. Both NR1 and NR2C are present in opossum kidney, Madin-Darby canine kidney, and LLC-PK1 cells. Immunohistochemistry studies show that the NR1 subunit is present in the renal proximal tubule. NR1 is abundant in the atrium and ventricle but is also expressed in the aorta and pulmonary artery. The NR2 subunits are not expressed in the heart. NR1 subunit protein expression is constant throughout heart development. Finally, the NR1 subunit protein is expressed in heart cells (H9c2) grown in culture. These studies reveal the presence of the NMDA receptor in the kidney and the cardiovascular system.

N-methyl-D-aspartate receptor; development


This article has been cited by other articles:


Home page
 HypertensionHome page
M.-C. Ma, H.-S. Huang, Y.-S. Chen, and S.-H. Lee
Mechanosensitive N-Methyl-D-Aspartate Receptors Contribute to Sensory Activation in the Rat Renal Pelvis
Hypertension, November 1, 2008; 52(5): 938 - 944.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
A. Vranyac-Tramoundanas, J. C. Harrison, A. N. Clarkson, M. Kapoor, I. C. Winburn, D. S. Kerr, and I. A. Sammut
Domoic Acid Impairment of Cardiac Energetics
Toxicol. Sci., October 1, 2008; 105(2): 395 - 407.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
C.-C. Yang, C.-T. Chien, M.-H. Wu, M.-C. Ma, and C.-F. Chen
NMDA receptor blocker ameliorates ischemia-reperfusion-induced renal dysfunction in rat kidneys
Am J Physiol Renal Physiol, June 1, 2008; 294(6): F1433 - F1440.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
H.-Y. Kim, C. Baylis, J. W. Verlander, K.-H. Han, S. Reungjui, M. E. Handlogten, and I. D. Weiner
Effect of reduced renal mass on renal ammonia transporter family, Rh C glycoprotein and Rh B glycoprotein, expression
Am J Physiol Renal Physiol, October 1, 2007; 293(4): F1238 - F1247.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
L. A. Slomowitz, F. B. Gabbai, S. J. Khang, J. Satriano, S. Thareau, A. Deng, S. C. Thomson, R. C. Blantz, and K. A. Munger
Protein intake regulates the vasodilatory function of the kidney and NMDA receptor expression
Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2004; 287(5): R1184 - R1189.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
K. G. Dickman, J. G. Youssef, S. M. Mathew, and S. I. Said
Ionotropic Glutamate Receptors in Lungs and Airways: Molecular Basis for Glutamate Toxicity
Am. J. Respir. Cell Mol. Biol., February 1, 2004; 30(2): 139 - 144.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online