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Am J Physiol Regul Integr Comp Physiol 283: R732-R738, 2002; doi:10.1152/ajpregu.00346.2001
0363-6119/02 $5.00
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Vol. 283, Issue 3, R732-R738, September 2002

Superoxide dismutase and oxidative stress in Dahl salt-sensitive and -resistant rats

Shumei Meng, L. Jackson Roberts II, Garrick W. Cason, Travis S. Curry, and R. Davis Manning Jr.

Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi 39216; and Department of Pharmacology, Vanderbilt University, Nashville, Tennessee 37232

The roles of oxidative stress and renal superoxide dismutase (SOD) levels and their association with renal damage were studied in Dahl salt-sensitive (S) and salt-resistant (R)/Rapp strain rats during changes in Na intake. After 3 wk of a high (8%)-Na diet in S rats, renal medullary Cu/Zn SOD was 56% lower and Mn SOD was 81% lower than in R high Na-fed rats. After 1, 2, and 3 wk of high Na, urinary excretion of F2-isoprostanes, an index of oxidative stress, was significantly greater in S rats compared with R rats. Plasma F2-isoprostane concentration increased in the 2-wk S high Na-fed group. After 3 wk, renal cortical and medullary superoxide production was significantly increased in Dahl S rats on high Na intake, and urinary protein excretion, an index of renal damage, was 273 ± 32 mg/d in S high Na-fed rats and 35 ± 4 mg/d in R high Na-fed rats (P < 0.05). In conclusion, salt-sensitive hypertension in the S rat is accompanied by marked decreases in renal medullary SOD and greater renal oxidative stress and renal damage than in R rats.

urinary protein excretion; isoprostane; dietary sodium; renal damage


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