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Am J Physiol Regul Integr Comp Physiol 283: R441-R450, 2002. First published May 6, 2002; doi:10.1152/ajpregu.00669.2001
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Vol. 283, Issue 2, R441-R450, August 2002

Sympathetic-renal interaction in chronic arterial pressure control

Olaf Grisk1, Hans-Joachim Rose2, Gerd Lorenz3, and Rainer Rettig1

Departments of 1 Physiology, 2 Clinical Chemistry, and 3 Pathology, Ernst-Moritz-Arndt-University, D-17487 Greifswald, Germany

The effects of neonatal sympathectomy of donors or recipients on posttransplantation arterial pressure were investigated in spontaneously hypertensive rats (SHR) by renal transplantation experiments. Conscious mean arterial pressure (MAP) and renal vascular resistance were 136 ± 1 mmHg and 15.5 ± 1.2 mmHg · ml-1 · min · g in sympathectomized SHR (n = 8) vs. 158 ± 4 mmHg (P < 0.001) and 20.8 ± 1.1 mmHg · ml-1 · min · g (P < 0.05) in controls (n = 10). Seven weeks after transplantation of a kidney from neonatally sympathectomized SHR donors, MAP in SHR recipients (n = 10) was 20 mmHg lower than in controls transplanted with a kidney from hydralazine-treated SHR (n = 10) (P < 0.05) associated with reduced sodium sensitivity of MAP. Neonatal sympathectomy also lowered MAP in F1-hybrids (F1H; SHR × Wistar-Kyoto rats). Within 6 wk after transplantation, renal grafts from untreated SHR increased MAP by 20 mmHg in sympathectomized F1H (n = 10) and by 35 mmHg in sham-treated F1H (n = 8) (P < 0.05). Neonatal sympathectomy induces chronic changes in SHR kidney function leading to a MAP reduction even when extrarenal sympathetic tone is restored. Generalized reduction in sympathetic tone resets the kidney-fluid system to reduced MAP and blunts the extent of arterial pressure rise induced by an SHR kidney graft.

rats; inbred strains; kidney transplantation; sodium; catecholamines; guanethidine


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