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Veterans Affairs Medical Center, Geriatric, Research, Education and Clinical Center and Research Service, Minneapolis 55417; and Department of Food Science and Nutrition, University of Minnesota, St. Paul, Minnesota 55108
The intermediate portion of the lateral
septum (LSi) contains high levels of urocortin (UCN) peptide and type 2 corticotropin-releasing hormone (CRH) receptor (CRHR2) and has anatomic
and functional connections with the lateral hypothalamus (LH). We
tested the effect of UCN in the LSi on feeding. Injection of 10 or 30 pmol UCN into LSi significantly decreased feeding in food-deprived rats
for 24 h without producing conditioned taste aversion (CTA). Pretreatment with a CRH receptor antagonist, 
-helical CRH
(-hCRH), blocked the inhibitory effect of UCN on deprivation-induced
feeding at 1 and 2 h postinjection. Furthermore, UCN in the LSi
significantly decreased feeding induced by LH-injected orexin A
at 2 and 4 h postinjection, and addition of -hCRH blocked the
inhibitory effect of UCN on orexin A-induced feeding. In
conclusion, UCN significantly inhibits feeding induced by
deprivation and LH-injected orexin A without producing a CTA, an effect
that is mediated by CRHR2. These data define the LSi as an important
site for UCN-induced anorexia and indicate that LSi UCN may influence
orexin A feeding signals in the LH.
intermediate portion of lateral septum; corticotropin releasing hormone receptor; satiety
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