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Am J Physiol Regul Integr Comp Physiol 283: R99-R106, 2002. First published March 29, 2002; doi:10.1152/ajpregu.00008.2002
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Vol. 283, Issue 1, R99-R106, July 2002

GLP-1 receptor signaling contributes to anorexigenic effect of centrally administered oxytocin in rats

Linda Rinaman and Elizabeth E. Rothe

Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260

The present study examined possible interactions between central glucagon-like peptide-1 (GLP-1) and oxytocin (OT) neural systems by determining whether blockade of GLP-1 receptors attenuates OT-induced anorexia and vice versa. Male rats were acclimated to daily 4-h food access. In the first experiment, rats were infused centrally with GLP-1 receptor antagonist or vehicle, followed by an anorexigenic dose of synthetic OT. Access to food began 20 min later. Cumulative food intake was measured every 30 min for 4 h. In the second experiment, rats were infused with OT receptor blocker or vehicle, followed by synthetic GLP-1 [(7-36) amide]. Subsequent food intake was monitored as before. The anorexigenic effect of OT was eliminated in rats pretreated with the GLP-1 receptor antagonist. Conversely, GLP-1-induced anorexia was not affected by blockade of OT receptors. In a separate immunocytochemical study, OT-positive terminals were found closely apposed to GLP-1-positive perikarya, and central infusion of OT activated c-Fos expression in GLP-1 neurons. These findings implicate endogenous GLP-1 receptor signaling as an important downstream mediator of anorexia in rats after activation of central OT neural pathways.

food intake; paraventricular nucleus of the hypothalamus; dorsal vagal complex


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