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Am J Physiol Regul Integr Comp Physiol 283: R46-R53, 2002; doi:10.1152/ajpregu.00021.2002
0363-6119/02 $5.00
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Vol. 283, Issue 1, R46-R53, July 2002

INVITED REVIEW
Principles for interpreting interactions among the multiple systems that influence food intake

Randy J. Seeley1 and Timothy H. Moran2

1 Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio 45267-0559; and 2 Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

The widespread use of molecular biological tools has led to a pronounced increase in the number of signals that are now implicated in the controls of food intake and body weight. However, a complete understanding of the roles of these multiple signals requires that we assess how they interact with one another to alter ingestive behavior. Although many such experiments are being conducted, the methods employed to delineate these interactions are often fraught with interpretive difficulties. The purpose of this article is to explore these difficulties and offer practical advice for minimizing these issues in experiments that seek to explore the important interactions among these signals. In particular, the issues of additive vs. nonadditive results, the use of sub- or suprathreshold dose combinations, and the choosing of multiple-dose analyses are all addressed. Furthermore, the possibilities of using intake measures other than cumulative intake and complementary nonbehavioral endpoints are encouraged.

dose-effect curve; leptin; multiple-dose combination; obesity; peptide


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