AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 282: R1593-R1599, 2002. First published January 31, 2002; doi:10.1152/ajpregu.00695.2001
0363-6119/02 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
282/6/R1593    most recent
00695.2001v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (9)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mollanji, R.
Right arrow Articles by Johnston, M. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mollanji, R.
Right arrow Articles by Johnston, M. G.
Vol. 282, Issue 6, R1593-R1599, June 2002

Blocking cerebrospinal fluid absorption through the cribriform plate increases resting intracranial pressure

R. Mollanji, R. Bozanovic-Sosic, A. Zakharov, L. Makarian, and M. G. Johnston

Trauma Research Program, Department of Laboratory Medicine and Pathobiology, Sunnybrook and Women's College Health Sciences Centre, University of Toronto, Toronto, Ontario M4N 3M5, Canada

Cerebrospinal fluid (CSF) drains through the cribriform plate (CP) in association with the olfactory nerves. From this location, CSF is absorbed into nasal mucosal lymphatics. Recent data suggest that this pathway plays an important role in global CSF transport in sheep. In this report, we tested the hypothesis that blocking CSF transport through this pathway would elevate resting intracranial pressure (ICP). ICP was measured continuously from the cisterna magna of sheep before and after CP obstruction in the same animal. To block CSF transport through the CP, an external ethmoidectomy was performed. The olfactory and adjacent mucosa were removed, and the bone surface was sealed with tissue glue. To restrict our analysis to the cranial CSF system, CSF transport into the spinal subarachnoid compartment was prevented with a ligature tightened around the thecal sac between C1 and C2. Sham surgical procedures had no significant effects, but in the experimental group CP obstruction elevated ICP significantly. Mean postobstruction steady-state pressures (18.0 ± 3.8 cmH2O) were approximately double the preobstruction values (9.2 ± 0.9 cmH2O). These data support the concept that the olfactory pathway represents a major site for CSF drainage.

lymphatic vessels; olfactory pathway; arachnoid villi; hydrocephalus


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
G. Nagra, J. Li, J. P. McAllister II, J. Miller, M. Wagshul, and M. Johnston
Impaired lymphatic cerebrospinal fluid absorption in a rat model of kaolin-induced communicating hydrocephalus
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2008; 294(5): R1752 - R1759.
[Abstract] [Full Text] [PDF]

Home page
 PhysiologyHome page
M. Johnston and C. Papaiconomou
Cerebrospinal Fluid Transport: a Lymphatic Perspective
Physiology, December 1, 2002; 17(6): 227 - 230.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
C. Papaiconomou, R. Bozanovic-Sosic, A. Zakharov, and M. Johnston
Does neonatal cerebrospinal fluid absorption occur via arachnoid projections or extracranial lymphatics?
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2002; 283(4): R869 - R876.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online