AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 282: R1219-R1226, 2002. First published December 21, 2001; doi:10.1152/ajpregu.00507.2001
0363-6119/02 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
282/4/R1219    most recent
00507.2001v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (7)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Dragon, S.
Right arrow Articles by Baumann, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dragon, S.
Right arrow Articles by Baumann, R.
Vol. 282, Issue 4, R1219-R1226, April 2002

cAMP and in vivo hypoxia induce tob, ifr1, and fos expression in erythroid cells of the chick embryo

Stefanie Dragon1, Nina Offenhäuser2,3, and Rosemarie Baumann1

1 Physiologisches Institut, Universität Regensburg, 93053 Regensburg, Germany; 2 European Institute for Oncology, 20141 Milan; and 3 FIRC Institute for Molecular Oncology, 20139 Milan, Italy

During avian embryonic development, terminal erythroid differentiation occurs in the circulation. Some of the key events, such as the induction of erythroid 2,3-bisphosphoglycerate (2,3-BPG), carbonic anhydrase (CAII), and pyrimidine 5'-nucleotidase (P5N) synthesis are oxygen dependent (Baumann R, Haller EA, Schöning U, and Weber M, Dev Biol 116: 548-551, 1986; Dragon S and Baumann R, Am J Physiol Regulatory Integrative Comp Physiol 280: R870-R878, 2001; Dragon S, Carey C, Martin K, and Baumann R, J Exp Biol 202: 2787-2795, 1999; Dragon S, Glombitza S, Götz R, and Baumann R, Am J Physiol Regulatory Integrative Comp Physiol 271: R982-R989, 1996; Dragon S, Hille R, Götz R, and Baumann R, Blood 91: 3052-3058, 1998; Million D, Zillner P, and Baumann R, Am J Physiol Regulatory Integrative Comp Physiol 261: R1188-R1196, 1991) in an indirect way: hypoxia stimulates the release of norepinephrine (NE)/adenosine into the circulation (Dragon et al., J Exp Biol 202: 2787-2795, 1999; Dragon et al., Am J Physiol Regulatory Integrative Comp Physiol 271: R982-R989, 1996). This leads via erythroid beta -adrenergic/adenosine A2 receptor activation to a cAMP signal inducing several proteins in a transcription-dependent manner (Dragon et al., Am J Physiol Regulatory Integrative Comp Physiol 271: R982-R989, 1996; Dragon et al., Blood 91: 3052-3058, 1998; Glombitza S, Dragon S, Berghammer M, Pannermayr M, and Baumann R, Am J Physiol Regulatory Integrative Comp Physiol 271: R973-R981, 1996). To understand how the cAMP-dependent processes are initiated, we screened an erythroid cDNA library for cAMP-regulated genes. We detected three genes that were strongly upregulated (>5-fold) by cAMP in definitive and primitive red blood cells. They are homologous to the mammalian Tob, Ifr1, and Fos proteins. In addition, the genes are induced in the intact embryo during short-term hypoxia. Because the genes are regulators of proliferation and differentiation in other cell types, we suggest that cAMP might promote general differentiating processes in erythroid cells, thereby allowing adaptive modulation of the latest steps of erythroid differentiation during developmental hypoxia.

erythropoiesis; terminal differentiation; adaptation; gene expression


This article has been cited by other articles:


Home page
 Nucleic Acids ResHome page
C. D. Deppmann, A. Acharya, V. Rishi, B. Wobbes, S. Smeekens, E. J. Taparowsky, and C. Vinson
Dimerization specificity of all 67 B-ZIP motifs in Arabidopsis thaliana: a comparison to Homo sapiens B-ZIP motifs
Nucleic Acids Res., June 29, 2004; 32(11): 3435 - 3445.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
M. Mass, E. Simo, and S. Dragon
Erythroid pyrimidine 5'-nucleotidase: cloning, developmental expression, and regulation by cAMP and in vivo hypoxia
Blood, December 1, 2003; 102(12): 4198 - 4205.
[Abstract] [Full Text] [PDF]

Home page
 PhysiologyHome page
S. Dragon and R. Baumann
Hypoxia, Hormones, and Red Blood Cell Function in Chick Embryos
Physiology, April 1, 2003; 18(2): 77 - 82.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
K. Ruijtenbeek, J. G. R. De Mey, C. E. Blanco ;, and H. Ehmke
The Chicken Embryo in Developmental Physiology of the Cardiovascular System: A Traditional Model with New Possibilities
Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2002; 283(2): R549 - R551.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online