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Am J Physiol Regul Integr Comp Physiol 282: R1185-R1190, 2002; doi:10.1152/ajpregu.00419.2001
0363-6119/02 $5.00
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Vol. 282, Issue 4, R1185-R1190, April 2002

Glycerokinase activity in brown adipose tissue: a sympathetic regulation?

N. H. Kawashita, W. T. L. Festuccia, M. N. Brito, M. A. F. Moura, S. R. C. Brito, M. A. R. Garófalo, I. C. Kettelhut, and R. H. Migliorini

Departments of Biochemistry, Immunology and Physiology, School of Medicine, University of São Paulo, Ribeirão Preto, 14049-900 São Paulo, Brazil

The effect of brown adipose tissue (BAT) sympathetic hemidenervation on the activity of glycerokinase (GyK) was investigated in different physiological conditions. In rats fed a balanced diet, the activity of the enzyme was ~50% lower in BAT-denervated pads than in intact, innervated pads. In rats adapted to a high-protein, carbohydrate-free diet, norepinephrine turnover rates and BAT GyK activity were already reduced, and BAT denervation resulted in a further decrease in the activity of the enzyme. Cold acclimation of normally fed rats at 4°C for 10 days markedly increased the activity of the enzyme. Cold exposure (4°C) for 6 h was insufficient to stimulate BAT GyK, but the activity of the enzyme was already increased after 12 h of cold exposure. The cold-induced BAT GyK stimulation was completely blocked in BAT-denervated pads. The data indicate that an adequate sympathetic flow to BAT is required for the maintenance of normal levels of GyK activity and for the enzyme response to situations, such as cold exposure, which markedly increase BAT sympathetic flow.

brown adipose tissue hemidenervation; high protein; carbohydrate-free diet; cold exposure


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