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Departments of 1 Nutritional Sciences, 4 Food Microbiology and Toxicology, and 5 Animal Sciences, College of Agricultural and Life Sciences; 3 Department of Surgical Sciences, School of Veterinary Medicine; and 2 Department of Chemistry, College of Letters and Science, University of Wisconsin-Madison, Madison, Wisconsin 53706
This
study investigated the capacity of conjugated linoleic acids (CLA) to
reduce ex vivo antigen-induced release of eicosanoids in a type I
hypersensitivity model. Guinea pigs were fed a diet containing 0.25%
safflower oil (control) or 0.25% CLA [43% trans (t)10, cis (c)12; 41% c9,
t11/t9, c11 18:2] for 2 wk before and during sensitization to ovalbumin (OVA). Lungs, tracheas, and bladders were incubated in physiological saline solution (PSS) for
1 h (basal mediator release) and challenged with OVA (0.01 g/l
PSS) for 1 h (mediator release in response to antigen).
Eicosanoids were quantified by HPLC/tandem mass spectrometry or enzyme
immunoassay. CLA feeding resulted in no change in basal release but
decreased eicosanoid release from sensitized tissues in response to
antigen challenge in the following manner: thromboxane B2,
6-keto-prostaglandin (PG)F1
, PGF2,
PGD2, PGE2 by 57-75% in lung,
45-65% in trachea, and 38-60% in bladder; and leukotriene
C4/D4/E4 by 87, 90, and 50% in
lung, trachea, and bladder, respectively. These data indicate
that feeding CLA reduces lipid-derived inflammatory mediators produced
by this type I hypersensitivity model.
type I hypersensitivity; lung; trachea; bladder
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