| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205; and 2 Bourne Behavioral Research Laboratory, Weill Medical College of Cornell University, White Plains, New York 10605
Peptides from cocaine- and amphetamine-regulated transcript (CART) reduce food intake in rats when injected into the lateral ventricle. Hypothalamic and hindbrain sites important in the control of feeding contain CART-immunoreactive fibers. To further define the site of CART's anorectic action, we compared feeding and other behavioral responses to third or fourth ventricular (3V, 4V) CART-(55-102) in 6-h food-deprived rats, both before and after cerebral aqueduct occlusion. 3V CART reduced the volume of Ensure consumed and resulted in fewer observations of eating and grooming within the 30-min test session. These reductions were significantly attenuated by aqueduct obstruction. 4V CART suppressed Ensure intake and resulted in decreased observations of feeding both with and without aqueduct blockade. 3V CART produced flat-backed postures and movement-associated tremors that were prevented by aqueduct obstruction. 4V CART also produced these signs, both with and without aqueduct blockade. We conclude that the major hypophagic effect of intracerebroventricular CART is mediated at a hindbrain site. The association of CART-induced feeding suppression with altered motor behavior questions the specificity of intracerebroventricular CART for actions on feeding.
cocaine- and amphetamine-regulated transcript feeding; hypothalamus
This article has been cited by other articles:
|
|
 |
|
  G. de Lartigue, R. Dimaline, A. Varro, and G. J. Dockray Cocaine- and Amphetamine-Regulated Transcript: Stimulation of Expression in Rat Vagal Afferent Neurons by Cholecystokinin and Suppression by Ghrelin J. Neurosci., March 14, 2007; 27(11): 2876 - 2882. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Blumberg, D. Haba, M. Schroeder, G. P. Smith, and A. Weller Independent ingestion and microstructure of feeding patterns in infant rats lacking CCK-1 receptors Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2006; 290(1): R208 - R218. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. F. Faulconbridge, H. J. Grill, and J. M. Kaplan Distinct Forebrain and Caudal Brainstem Contributions to the Neuropeptide Y Mediation of Ghrelin Hyperphagia Diabetes, July 1, 2005; 54(7): 1985 - 1993. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Blevins, M. W. Schwartz, and D. G. Baskin Evidence that paraventricular nucleus oxytocin neurons link hypothalamic leptin action to caudal brain stem nuclei controlling meal size Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2004; 287(1): R87 - R96. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Scruggs, S. L. Dun, and N. J. Dun Cocaine- and amphetamine-regulated transcript peptide attenuates phenylephrine-induced bradycardia in anesthetized rats Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2003; 285(6): R1496 - R1503. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. A. Cupples Peptides that regulate food intake Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2003; 284(6): R1370 - R1374. [Full Text] [PDF]
|
|
|
|
|
|
W. A. Cupples Regulating food intake Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2003; 284(3): R652 - R654. [Full Text] [PDF]
|
|
|
|
|
|
W. A. Cupples Regulation of body weight Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2002; 282(5): R1264 - R1266. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
