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Am J Physiol Regul Integr Comp Physiol 281: R1633-R1636, 2001;
0363-6119/01 $5.00
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Vol. 281, Issue 5, R1633-R1636, November 2001

Possible contribution of brain angiotensin III to ingestive behaviors in baboons

J. R. Blair-West1,2, K. D. Carey1,3, D. A. Denton1,4, L. J. Madden1, R. S. Weisinger4, and R. E. Shade1

1 Department of Physiology and Medicine and 3 Southwest Regional Primate Research Center, Southwest Foundation for Biomedical Research, San Antonio, Texas 78245-0549; and 2 Department of Physiology and 4 Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria 3010, Australia

Recent experiments with specific aminopeptidase inhibitors in rats have strengthened earlier proposals that ANG III may be an important regulatory peptide in the brain. Central mechanisms regulating blood pressure, ingestive behaviors, and vasopressin release could be involved. Arguments in favor of a role for ANG III depend, in part, on the efficacy of ANG III as an agonist. These first studies in primates tested whether ANG III stimulates ingestive behaviors in baboons. Intracerebroventricular (ICV) infusions of ANG III were as potent as ANG II in stimulating water drinking and intake of NaCl solution. On the basis of this criterion and consistent with findings in rats, ANG III could be a main effector peptide in the regulation of ingestive behaviors in a primate.

angiotensin II; sodium intake; water intake; intracerebroventricular infusion


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