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Am J Physiol Regul Integr Comp Physiol 281: R1449-R1455, 2001;
0363-6119/01 $5.00
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Vol. 281, Issue 5, R1449-R1455, November 2001

Vascular function in alcohol-treated pregnant and nonpregnant mice

Jocelynn L. Cook1, Yunlong Zhang1, and Sandra T. Davidge1,2

Departments of 1 Obstetrics and Gynecology and 2 Physiology, Perinatal Research Centre, University of Alberta, Edmonton, Alberta, Canada T6G-2S2

The effect of alcohol on maternal vascular adaptations to pregnancy is unknown. This study was designed to determine the effect of alcohol consumption on nitric oxide-mediated vascular function in mice during pregnancy. Female pregnant or nonpregnant C57BL/6J mice were fed a control diet or a liquid diet of 25% ethanol-derived calories for 13 days (from gestational days 6-18). Phenylephrine vasoconstriction was blunted in pregnancy compared with the nonpregnant state due to enhanced nitric oxide modulation, which was impaired by ethanol exposure. Although the EC50 and maximal responses to methacholine were not different in nonpregnant vs. pregnant mice, the nitric oxide component to methacholine-induced vasorelaxation was greater in the pregnant mice. Interestingly, alcohol affected only the pregnant animals in their response to methacholine. These data indicate that alcohol reduced the nitric oxide modulation of vascular response, which was more pronounced during pregnancy. These studies provide novel information regarding the effects of alcohol on the maternal vascular system during pregnancy and thereby contribute to further understanding of the adverse effects associated with prenatal alcohol exposure.

nitric oxide; mouse


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