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University of Colorado at Boulder, Department of Kinesiology and Applied Physiology, Boulder, Colorado 80309
The current study addressed whether physical activity can buffer stress-induced "behavioral depression" and immunosuppression. Adult, male Sprague-Dawley rats were housed with either a mobile (physically active) or immobile (sedentary) running wheel and exposed to either stress (inescapable tail shock) or no stress (home cage control). Voluntary wheel running began 4 wk before stressor exposure. Immediately before stress, all rats were administered an intraperitoneal injection of keyhole limpet hemocyanin (KLH; 200 µg), and anti-KLH Ig was measured weekly for 4 wk using ELISA. Prior physical activity reduced the stress-induced behavioral depression and prevented the stress-induced suppression of anti-KLH IgM and IgG2a antibodies. Anti-KLH IgG1 was stress insensitive. These data suggest that physical activity can buffer the negative impact of stress on behavior and acquired immune function.
keyhole limpet hemocyanin; exercise; wheel running
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