AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 281: R401-R407, 2001;
0363-6119/01 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (13)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Porter, G. A.
Right arrow Articles by Rivkees, S. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Porter, G. A., Jr.
Right arrow Articles by Rivkees, S. A.
Vol. 281, Issue 2, R401-R407, August 2001

Ontogeny of humoral heart rate regulation in the embryonic mouse

George A. Porter Jr.1 and Scott A. Rivkees2

Department of Pediatrics, Divisions of 1 Cardiology and 2 Endocrinology, Yale University School of Medicine, New Haven, Connecticut 06520

Catecholamines, acetylcholine, and adenosine are known to influence cardiac function, yet the effects of these agents on mammalian embryonic myocardium are largely unknown. To address this issue, we compared the chronotrophic effects of adenosinergic, adrenergic, and muscarinic agents on cultured murine embryos from postcoital day (PC) 8.0, when the fusing heart tubes first begin to beat, to PC 14, when cardiogenesis is essentially complete. At PC 8.0 and older, A1-adenosine receptor (A1AR) activation significantly decreased heart rates. Adrenergic stimulation caused modest increases in heart rates (145-155% of baseline) beginning at PC 9.0. Muscarinic activation decreased heart rates only after PC 13. When receptor gene expression was examined, A1ARs and beta 1ARs were expressed in isolated hearts as early as PC 9.0, and beta 2ARs and m2-muscarinic receptor genes were expressed at PC 11.0. These results identify the adenosinergic system as the earliest and most potent regulator of embryonic cardiac function and show that prenatal responsiveness to catecholamines and acetylcholine develops at later embryonic stages.

adenosine; catecholamines; acetylcholine; embryo


This article has been cited by other articles:


Home page
 J. Physiol.Home page
Y. Qu, G. M. Whitaker, L. Hove-Madsen, G. F. Tibbits, and E. A. Accili
Hyperpolarization-activated cyclic nucleotide-modulated 'HCN' channels confer regular and faster rhythmicity to beating mouse embryonic stem cells
J. Physiol., February 1, 2008; 586(3): 701 - 716.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
A. Mery, F. Aimond, C. Menard, K. Mikoshiba, M. Michalak, and M. Puceat
Initiation of Embryonic Cardiac Pacemaker Activity by Inositol 1,4,5-Trisphosphate-dependent Calcium Signaling
Mol. Biol. Cell, May 1, 2005; 16(5): 2414 - 2423.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
H. M. Stauss
Heart rate variability
Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2003; 285(5): R927 - R931.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
A. Rosa, J.-P. Maury, J. Terrand, X. Lyon, P. Kucera, L. Kappenberger, and E. Raddatz
Ectopic pacing at physiological rate improves postanoxic recovery of the developing heart
Am J Physiol Heart Circ Physiol, June 1, 2003; 284(6): H2384 - H2392.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
H. Ehmke
Developmental physiology of the cardiovascular system
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2002; 282(2): R331 - R333.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. C. Garofolo, F. J. Seidler, J. T. Auman, and T. A. Slotkin
beta -Adrenergic modulation of muscarinic cholinergic receptor expression and function in developing heart
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2002; 282(5): R1356 - R1363.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online