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-pregnan-3-ol-20-one on nitric
oxide biosynthesis and plasma volume in rats
Department of Physiology, University of Alberta, Edmonton, Alberta T6G 2S2, Canada
Plasma
5
-pregnan-3-ol-20-one (pregnan) levels and nitric oxide
(NO) biosynthesis increase during pregnancy. These factors have
independently been implicated in the control of blood pressure and
volume. We wished to determine whether pregnan might be responsible both for the increase in NO biosynthesis and for the increase in plasma
volume observed during pregnancy. Virgin female Long-Evans rats were
implanted with indwelling cannulas and maintained on a low
nitrate/nitrite diet. After the rats recovered from surgery, 500 µg of pregnan or vehicle were given daily for 2 days. NO
biosynthesis and plasma volume were measured in conscious animals
before and after treatment. Pregnan caused a significant increase in NO
biosynthesis (1.9 ± 0.8 µmol/24 h, n = 10)
compared with the vehicle-treated control group (0.3 ± 0.4 µmol/24 h, n = 10, P < 0.05).
Similarly, there was a significant increase in plasma volume in the
pregnan-treated group (0.7 ± 0.2 ml/100 g, n = 11) compared with the vehicle-treated control group (0.2 ± 0.1 ml/100 g, n = 11, P < 0.05). These
results confirm that pregnan can mimic pregnancy by its ability to
increase both NO biosynthesis and plasma volume.
allopregnanolone; blood volume; pregnancy
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