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Am J Physiol Regul Integr Comp Physiol 280: R1613-R1619, 2001;
0363-6119/01 $5.00
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Vol. 280, Issue 6, R1613-R1619, June 2001

Intracerebroventricular CART peptide reduces rat ingestive behavior and alters licking microstructure

Susan Aja1, Gary J. Schwartz1, Michael J. Kuhar2, and Timothy H. Moran1

1 Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205; and 2 Yerkes Regional Primate Research Center, Emory University, Atlanta, Georgia 30329

Intracerebroventricular administration of cocaine- and amphetamine-regulated transcript (CART) peptides reduces food intake and increases c-Fos in brain areas involved in the control of feeding. To discern behavioral mechanisms through which CART alters the microstructure of feeding, we injected CART-(55-102) (0.1, 0.5, 1, 2 µg, and saline controls) into the lateral ventricle of male Sprague-Dawley rats 5 min before dark onset and, using lickometers, monitored the ingestion of an Ensure liquid diet for the first 6 h of dark. At a threshold dose of 1 µg, CART dose dependently 1) decreased intake of Ensure in licks; 2) decreased meal size, but did not alter meal duration or number; 3) reduced initial lick rate of meals; and 4) significantly reduced burst number, licks/burst, and licks/cluster. CART dose dependently increased interlick interval (0.5 µg threshold, 192 ± 4 vs. 183 ± 3 ms, control; 1 µg: 201 ± 1 ms; 2 µg: 214 ± 6 ms). These data suggest that altered oral motor function, and possibly palatability perception, may be fundamental to the anorexigenic action of CART.

hypophagia; peptides; hypothalamus; hindbrain


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