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Am J Physiol Regul Integr Comp Physiol 280: R1582-R1591, 2001;
0363-6119/01 $5.00
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Vol. 280, Issue 5, R1582-R1591, May 2001

Melatonin or a melatonin agonist corrects age-related changes in circadian response to environmental stimulus

Olivier Van Reeth1, Laurence Weibel1, Elisabeth Olivares1, Sonia Maccari1, Elisabeth Mocaer2, and Fred William Turek1

1 Centre d'Etudes des Rythmes Biologiques, School of Medicine, Hôpital Erasme, Université Libre de Bruxelles, 1070 Brussels, Belgium; and 2 Department of Neurobiology, Institut de Recherches Internationales Servier, 92415 Courbevoie, France

The effects of a melatonin agonist, S-20098, included in the diet were tested on a specific effect of aging in hamsters: the marked decline in the phase shifting effects of a 6-h pulse of darkness on a background of constant light. In contrast to young hamsters, old hamsters fed with the control diet showed little or no phase shifts in response to a dark pulse presented in the middle of their inactive or active period. Old hamsters fed with S-20098 showed phase shifts that were ~70% of the ones in young animals and significantly greater than those in old controls. The phase advancing response to a dark pulse presented during the inactive period was dose dependent and reversed after S-20098 discontinuation. Melatonin included in the diet showed comparable restorative effects on the phase shifting response to a dark pulse in old hamsters. Replacement therapy with melatonin or melatonin-related compounds could prove useful in treating, preventing, or delaying disturbances of circadian rhythmicity and/or sleep in older people.

aging; circadian rhythm; sleep


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