AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 280: R1261-R1268, 2001;
0363-6119/01 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (12)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Miyawaki, T.
Right arrow Articles by Pilowsky, P. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Miyawaki, T.
Right arrow Articles by Pilowsky, P. M.
Vol. 280, Issue 5, R1261-R1268, May 2001

Rostral ventral medulla 5-HT1A receptors selectively inhibit the somatosympathetic reflex

Takashi Miyawaki, Ann K. Goodchild, and Paul M. Pilowsky

Hypertension and Stroke Research Laboratories, Departments of Physiology and Neurosurgery, University of Sydney, Royal North Shore Hospital, St. Leonards, New South Wales, Australia 2065

The role of the 5-hydroxytryptamine (5-HT1A) receptors in the rostral ventrolateral medulla (RVLM) on somatosympathetic, baroreceptor, and chemoreceptor reflexes was examined in anesthetized rats. Microinjection of the selective 5-HT1A agonist 8-hydroxy-di-n-propylamino tetralin (8-OH-DPAT) decreased arterial blood pressure and splanchnic sympathetic nerve activity (SNA). Electrical stimulation of the hindlimb evoked early and late excitatory sympathetic responses. Bilateral microinjection in the RVLM of 8-OH-DPAT markedly attenuated both the early and late responses. This potent inhibition of the somatosympathetic reflex persisted even after SNA and arterial blood pressure returned to preinjection levels. Preinjection of the selective 5-HT1A antagonist NAN-190 in the RVLM blocked the sympathoinhibitory effect of 8-OH-DPAT and attenuated the inhibitory effect on the somatosympathetic reflex. 8-OH-DPAT injected in the RVLM did not affect baroreceptor or chemoreceptor reflexes. Our findings suggest that activation of 5-HT1A receptors in the RVLM exerts a potent, selective inhibition on the somatosympathetic reflex.

5-hydroxytryptamine; baroreceptor; chemoreceptor; 8-hydroxy-di-n-propylamino tetralin; NAN-190


This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
C. M. Hildreth, J. R. Padley, P. M. Pilowsky, and A. K. Goodchild
Impaired serotonergic regulation of heart rate may underlie reduced baroreflex sensitivity in an animal model of depression
Am J Physiol Heart Circ Physiol, January 1, 2008; 294(1): H474 - H480.
[Abstract] [Full Text] [PDF]

Home page
 Exp PhysiolHome page
A. K. Curran and J. C. Leiter
Respiratory: Baroreceptor-mediated inhibition of respiration after peripheral and central administration of a 5-HT1A receptor agonist in neonatal piglets
Exp Physiol, July 1, 2007; 92(4): 757 - 767.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
P. Osei-Owusu and K. Scrogin
Role of the arterial baroreflex in 5-HT1A receptor agonist-mediated sympathoexcitation following hypotensive hemorrhage
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2006; 290(5): R1337 - R1344.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. R. Padley, D. H. Overstreet, P. M. Pilowsky, and A. K. Goodchild
Impaired cardiac and sympathetic autonomic control in rats differing in acetylcholine receptor sensitivity
Am J Physiol Heart Circ Physiol, November 1, 2005; 289(5): H1985 - H1992.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. M. Makeham, A. K. Goodchild, and P. M. Pilowsky
NK1 receptor activation in rat rostral ventrolateral medulla selectively attenuates somato-sympathetic reflex while antagonism attenuates sympathetic chemoreflex
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2005; 288(6): R1707 - R1715.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
T. A. Verner, A. K. Goodchild, and P. M. Pilowsky
A mapping study of cardiorespiratory responses to chemical stimulation of the midline medulla oblongata in ventilated and freely breathing rats
Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2004; 287(2): R411 - R421.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
K. E. Scrogin
5-HT1A receptor agonist 8-OH-DPAT acts in the hindbrain to reverse the sympatholytic response to severe hemorrhage
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2003; 284(3): R782 - R791.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
H. M. Stauss
Baroreceptor reflex function
Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2002; 283(2): R284 - R286.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
C. Dean and M. Bago
Renal sympathoinhibition mediated by 5-HT1A receptors in the RVLM during severe hemorrhage in rats
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2002; 282(1): R122 - R130.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online