AJP - Regu AJP: Heart and Circulatory Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 280: R1134-R1140, 2001;
0363-6119/01 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (10)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Frank, M. G.
Right arrow Articles by Heller, H. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Frank, M. G.
Right arrow Articles by Heller, H. C.
Vol. 280, Issue 4, R1134-R1140, April 2001

Prenatal nicotine alters vigilance states and AchR gene expression in the neonatal rat: implications for SIDS

Marcos G. Frank2, Hilary Srere1, Carlos Ledezma1, Bruce O'Hara1, and H. Craig Heller1

1 Department of Biological Sciences, Stanford University, Stanford 94305; and 2 Department of Physiology, University of California at San Francisco, San Francisco, California 94143

Maternal smoking is a major risk factor for sudden infant death syndrome (SIDS). The mechanisms by which cigarette smoke predisposes infants to SIDS are not known. We examined the effects of prenatal nicotine exposure on sleep/wake ontogenesis and central cholinergic receptor gene expression in the neonatal rat. Prenatal nicotine exposure transiently increased sleep continuity and accelerated sleep/wake ontogeny in the neonatal rat. Prenatal nicotine also upregulated nicotinic and muscarinic cholinergic receptor mRNAs in brain regions involved in regulating vigilance states. These findings suggest that the nicotine contained in cigarette smoke may predispose human infants to SIDS by interfering with the normal maturation of sleep and wake.

smoking; sleep; sudden infant death syndrome; cholinergic receptors


This article has been cited by other articles:


Home page
 Am. J. Respir. Crit. Care Med.Home page
O. Hafstrom, J. Milerad, and H. W. Sundell
Prenatal Nicotine Exposure Blunts the Cardiorespiratory Response to Hypoxia in Lambs
Am. J. Respir. Crit. Care Med., December 15, 2002; 166(12): 1544 - 1549.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. P. Granger
Maternal and fetal adaptations during pregnancy: lessons in regulatory and integrative physiology
Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2002; 283(6): R1289 - R1292.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. C. Garofolo, F. J. Seidler, J. T. Auman, and T. A. Slotkin
beta -Adrenergic modulation of muscarinic cholinergic receptor expression and function in developing heart
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2002; 282(5): R1356 - R1363.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online