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Am J Physiol Regul Integr Comp Physiol 280: R143-R148, 2001;
0363-6119/01 $5.00
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Vol. 280, Issue 1, R143-R148, January 2001

Hemodynamic and renal effects of acute and progressive nitric oxide synthesis inhibition in anesthetized dogs

Aleix Cases, John Haas, John C. Burnett, and Juan Carlos Romero

Department of Physiology, Mayo Foundation, Rochester, Minnesota 55905

This study evaluated the effects of progressive nitric oxide (NO) inhibition in the regulation of systemic and regional hemodynamics and renal function in anesthetized dogs. The NG-nitro-L-arginine methyl ester group (n = 9) received progressive doses of 0.1, 1, 10, and 50 µg · kg-1 · min-1. Renal (RBF), mesenteric (MBF), iliac (IBF) blood flows, mean arterial pressure (MAP), pulmonary pressures, cardiac output (CO), and systemic and pulmonary vascular resistances were measured. During NG-nitro-L-arginine methyl ester infusion, MAP and systemic vascular resistances increased in a dose-dependent manner. Mean pulmonary pressure and pulmonary vascular resistances increased in both the NG-nitro-L-arginine methyl ester and the control group, but the increase was more marked in the NG-nitro-L-arginine methyl ester group during the last two infusion periods. CO decreased progressively, before any significant change in blood pressure was noticeable in the NG-nitro-L-arginine methyl ester group. IBF decreased significantly from the first NG-nitro-L-arginine methyl ester dose, whereas RBF and MBF only decreased significantly during the highest NG-nitro-L-arginine methyl ester dose. Urinary volume and sodium excretion only increased significantly in the time control group during the two last time periods. The pulmonary vasculature was more sensitive than the systemic vasculature, whereas skeletal muscle and renal vasculatures showed a greater sensitivity to the inhibition of NO production than the mesenteric vasculature. NO synthesis inhibition induces a progressive antidiuretic and antinatriuretic effect, which is partially offset by the increase in blood pressure.

NG-nitro-L-arginine methyl ester; regional blood flows; systemic hemodynamics; renal function; urinary sodium excretion


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