AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 279: R1205-R1214, 2000;
0363-6119/00 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (16)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by St-Pierre, J.
Right arrow Articles by Boutilier, R. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by St-Pierre, J.
Right arrow Articles by Boutilier, R. G.
Vol. 279, Issue 4, R1205-R1214, October 2000

Metabolic depression and enhanced O2 affinity of mitochondria in hypoxic hypometabolism

Julie St-Pierre, Glenn J. Tattersall, and Robert G. Boutilier

Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, United Kingdom

This study examined whether the steady-state hypometabolism seen in overwintering frogs (Rana temporaria) is reflected at the mitochondrial level either by a reduction in their resting (state 4) and active (state 3) respiration rates and/or by increases in O2 affinity. We isolated mitochondria from the skeletal muscle of cold-submerged frogs at different stages during their hibernation in normoxic and hypoxic water. A modest metabolic depression at the whole animal level (normoxic submergence) was not associated with a reduction in mitochondrial state 4 and state 3 respiration rates. However, mitochondria isolated from frogs that were submerged for 1 mo manifested an increase in their O2 affinity compared with controls and with animals submerged for 4 mo. Hypometabolism was more pronounced at the whole animal level during hypoxic submergence and was accompanied by 1) a reduction in mitochondrial state 4 and state 3 rates and 2) an increase in the O2 affinity of mitochondria. These findings demonstrate that metabolic depression can be reflected at all levels of biological organization in hypoxia-tolerant animals.

frog; hypoxia; state 3; state 4; P50


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. G. Richards, B. A. Sardella, and P. M. Schulte
Regulation of pyruvate dehydrogenase in the common killifish, Fundulus heteroclitus, during hypoxia exposure.
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2008; 295(3): R979 - R990.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. B. Pritchard
Comparative models and biological stress
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2002; 283(4): R807 - R809.
[Full Text] [PDF]

Home page
 J. Exp. Biol.Home page
H. Guderley and J. St-Pierre
Going with the flow or life in the fast lane: contrasting mitochondrial responses to thermal change
J. Exp. Biol., August 1, 2002; 205(15): 2237 - 2249.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Biol.Home page
R. G. Boutilier and J. St-Pierre
Adaptive plasticity of skeletal muscle energetics in hibernating frogs: mitochondrial proton leak during metabolic depression
J. Exp. Biol., August 1, 2002; 205(15): 2287 - 2296.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Biol.Home page
N. J. Hudson and C. E. Franklin
Maintaining muscle mass during extended disuse: aestivating frogs as a model species
J. Exp. Biol., August 1, 2002; 205(15): 2297 - 2303.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Biol.Home page
T. McKean, G. Li, and K. Wei
Cardiac effects of hypoxia in the neotenous tiger salamander Ambystoma tigrinum
J. Exp. Biol., June 15, 2002; 205(12): 1725 - 1734.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online