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Department of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73190
Extracellular potentials of 38 C1-C2 spinothalamic tract (STT) neurons in anesthetized monkeys
(Macaca fascicularis) were examined for responses to
intrapericardiac injections of an algogenic chemical mixture
(adenosine, 10
3 M; bradykinin, prostaglandin
E2, serotonin, histamine, each 105 M).
Chemical stimulation of cardiac/pericardiac receptors increased activity of 21 cells, decreased activity of 5 cells, and did not change
activity of 12 cells. Cells excited by chemical stimuli received input
from noxious mechanical stimulation of somatic fields; most receptive
fields included the neck, inferior jaw, or head areas. Nerve ablations
in 11 cells excited by intrapericardiac chemicals showed that cardiac
input activated by algogenic chemicals traveled primarily in vagal
afferent fibers to C1-C2 segments; phrenic or cardiopulmonary
sympathetic inputs were predominant in 2 of 11 cells. These results
supported the concept that activation of cardiac vagal afferents might
lead to the production of referred pain sensation in somatic fields
innervated from high cervical segments.
cardiac nociception; vagal afferents; referred pain
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