AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 278: R1453-R1459, 2000;
0363-6119/00 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (7)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Solhaug, M. J.
Right arrow Articles by Dong, K.-W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Solhaug, M. J.
Right arrow Articles by Dong, K.-W.
Vol. 278, Issue 6, R1453-R1459, June 2000

Ontogeny of neuronal nitric oxide synthase, NOS I, in the developing porcine kidney

Michael J. Solhaug1, Xui Q. Dong1, Raymond D. Adelman1, and Ke-Wen Dong2

1 Departments of Pediatrics, Physiology, and 2 Obstetrics and Gynecology, Eastern Virginia Medical School, Norfolk, Virginia 23507

To determine if the developing kidney differs from the adult in the expression of the neuronal nitric oxide synthase, NOS I, these experiments measured mRNA gene expression by RNase protection assay and protein content by Western blot of NOS I in piglets at ages newborn and 3, 7, 10, 14, and 21 days and adult pigs. Whole kidney NOS I mRNA was greatest at birth and decreased progressively during renal maturation to adult levels. NOS I protein content paralleled this developmental pattern. Cortical NOS I protein was equivalent in newborn and 14-day-old piglets and was greater at both ages than the adult. Medullary NOS I protein was relatively greater than cortical in both immature ages and decreased from a peak at birth to adult levels. We conclude the following. 1) During postnatal maturation, renal NOS I mRNA and protein content show a pattern that is developmentally regulated. 2) This developmental pattern of NOS I after birth may, in part, contribute to the enhanced functional role of NO during renal maturation.

development


This article has been cited by other articles:


Home page
 Am. J. Physiol. Renal Physiol.Home page
K.-H. Han, J.-M. Lim, W.-Y. Kim, H. Kim, K. M. Madsen, and J. Kim
Expression of endothelial nitric oxide synthase in developing rat kidney
Am J Physiol Renal Physiol, April 1, 2005; 288(4): F694 - F702.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
P. B. Persson
Nitric oxide in the kidney
Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2002; 283(5): R1005 - R1007.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
A. Sener and F. G. Smith
Glomerular and tubular responses to NG-nitro-L-arginine methyl ester are age dependent in conscious lambs
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2002; 282(5): R1512 - R1520.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
H. Ehmke
Developmental physiology of the cardiovascular system
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2002; 282(2): R331 - R333.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. J. Solhaug, U. Kullaprawithaya, X. Q. Dong, and K.-W. Dong
Expression of endothelial nitric oxide synthase in the postnatal developing porcine kidney
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2001; 280(5): R1269 - R1275.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online