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Am J Physiol Regul Integr Comp Physiol 278: R654-R662, 2000;
0363-6119/00 $5.00
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Vol. 278, Issue 3, R654-R662, March 2000

Insulin-like growth factor I mediates high-fat diet-induced adipogenesis in Osborne-Mendel rats

Brenda G. Marques, Dorothy B. Hausman, Amanda M. Latimer, Krystyna M. Kras, Barbara Mullen Grossman, and Roy J. Martin

Department of Foods and Nutrition, University of Georgia, Athens, Georgia 30602

To determine if high-fat (HF) diet-induced changes in adipose tissue cellularity are associated with the presence of paracrine growth factor(s) that alter preadipocyte proliferation, Osborne-Mendel rats were fed either a HF (76% energy) or a low-fat (LF, 12% energy) diet for 85 days. HF-fed rats had greater (P < 0.05) fat pad size, total fat cell number, number of small (30-70 µm) and large (80-140 µm) adipocytes, and percentage of 100- to 140-µm adipocytes compared with LF-fed rats. Preadipocytes in primary cell culture treated with inguinal adipose tissue conditioned medium (ATCM) prepared from HF-fed rats had greater (P < 0.05) proliferation compared with cultures treated with ATCM from LF-fed rats. Proliferative capacity of ATCM prepared from HF-fed rats was attenuated after the stripping of the medium of insulin-like growth factor I using an immunomagnetic bead separation system. These data are consistent with the concept that insulin-like growth factor I is involved in the paracrine regulation of adipogenesis.

adipocyte; obesity; proliferation


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