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Am J Physiol Regul Integr Comp Physiol 276: R1443-R1452, 1999;
0363-6119/99 $5.00
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Vol. 276, Issue 5, R1443-R1452, May 1999

Atrial, B-type, and C-type natriuretic peptides cause mesenteric vasoconstriction in conscious dogs

Robyn L. Woods1 and Marcus J. M. Jones2

1 Howard Florey Institute, University of Melbourne, Parkville, Victoria 3052; and 2 Baker Medical Research Institute, Prahran, Victoria 3181, Australia

Cardiovascular responses were compared with equimolar infusions of B-type (BNP) and C-type (CNP) with atrial natriuretic peptide (ANP) in conscious, instrumented dogs. On separate days, each natriuretic peptide or vehicle was infused (intravenously) at step-up doses of 2, 5, 10, and 20 pmol · kg-1 · min-1 (20 min each dose) to increase circulating levels of the infused peptide from ~2- to 20-fold. Like ANP, infusions of BNP caused dose-related increases (P < 0.05) in mesenteric vascular resistance, urine flow, natriuresis, and hematocrit (changes at highest doses were 60 ± 9, 334 ± 113, 313 ± 173, and 12 ± 2%, respectively). BNP also lowered (P < 0.05) plasma renin activity (-43 ± 11%) and arterial pressure (-10 ± 3%). Effects of BNP were independent of reflex sympathetic activation, since autonomic ganglion blockade did not attenuate the responses. CNP infusions had little effect except to increase (P < 0.05) mesenteric vascular resistance (27 ± 10%) and plasma ANP (41 ± 7%). Cardiovascular actions of BNP, like those of ANP, counteract the renin-ANG system and may protect the heart by lowering cardiac preload (venous return) and afterload (arterial pressure) while maintaining blood flow to extrasplanchnic regions.

atrial natriuretic factor; blood pressure; atrial natriuretic peptide; brain natriuretic peptide; hemoconcentration; in vivo; kidney; plasma renin activity


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