AJP - Regu Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Regul Integr Comp Physiol 276: R1416-R1424, 1999;
0363-6119/99 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Nishimura, M.
Right arrow Articles by Yoshimura, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Nishimura, M.
Right arrow Articles by Yoshimura, M.
Vol. 276, Issue 5, R1416-R1424, May 1999

Regulation of brain renin-angiotensin system by benzamil-blockable sodium channels

Masato Nishimura1, Ken Ohtsuka1, Naoharu Iwai2, Hakuo Takahashi3, and Manabu Yoshimura1

1 Department of Clinical and Laboratory Medicine, Kyoto Prefectural University of Medicine, Kyoto 602-0841; 2 First Department of Internal Medicine, Shiga University of Medical Sciences, Shiga 520-2152; and 3 Department of Clinical Sciences and Laboratory Medicine, Kansai Medical University, Osaka 570-0074, Japan

Changes in the renin-angiotensin system (RAS) mRNAs in the brain and the kidney of rats after administration of DOCA and/or sodium chloride were assessed by use of a competitive PCR method. Benzamil, a blocker of amiloride-sensitive sodium channels, was infused intracerebroventricularly or intravenously for 7 days in DOCA-salt or renal hypertensive rats, and the effects of benzamil on the brain RAS mRNAs were determined. Renin and ANG I-converting enzyme (ACE) mRNAs were not downregulated in the brain of rats administered DOCA and/or salt; however, these mRNAs were decreased in the kidney. Intracerebroventricular infusion of benzamil decreased renin, ACE, and ANG II type 1 receptor mRNAs in the brain of DOCA-salt hypertensive rats but not in the brain of renal hypertensive rats. The gene expression of the brain RAS, particularly renin and ACE, is regulated differently between the brain and the kidney in DOCA-salt hypertensive rats, and benzamil-blockable brain sodium channels may participate in the regulation of the brain RAS mRNAs.

angiotensin I-converting enzyme; angiotensin II type 1 receptors; deoxycortisone acetate-salt hypertension


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
R. C. Speth, M. S. Smith, and K. L. Grove
Lactation decreases angiotensinogen mRNA expression in the midcaudal arcuate nucleus of the rat brain
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2001; 280(4): R1169 - R1176.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
T. R. Nurkiewicz and M. A. Boegehold
Reinforcement of arteriolar myogenic activity by endogenous ANG II: susceptibility to dietary salt
Am J Physiol Heart Circ Physiol, July 1, 2000; 279(1): H269 - H278.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online