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Am J Physiol Regul Integr Comp Physiol 275: R1633-R1638, 1998;
0363-6119/98 $5.00
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Vol. 275, Issue 5, R1633-R1638, November 1998

Interleukin-1beta -induced fever in young and old Long-Evans rats

Carlos R. Plata-Salamán1,2, Elizabeth Peloso3, and Evelyn Satinoff2,3

1 Department of Biological Sciences, 3 Department of Psychology, and 2 Program in Neuroscience, University of Delaware, Newark, Delaware 19716-2590

Aging is associated with a blunted or absent fever response to naturally occurring infections or to the peripheral administration of bacterial products and proinflammatory cytokines, including interleukin-1beta (IL-1beta ). Whether old rats also exhibit an attenuated fever response when challenged with direct brain administration of IL-1beta is unknown. Here we investigated the fever response of young (3-5 mo) and old (24-26 mo) Long-Evans rats to the intracerebroventricular microinfusion of IL-1beta . Core body temperature was monitored by telemetry in freely moving rats. Intracerebroventricularly administered IL-1beta induced comparable increases in body temperature in young and old Long-Evans rats. In the two groups, IL-1beta -induced fever was similar both in latency to peak fever and maximal fever response, whether the cytokine was administered 2 h after lights on or just before lights off. These data show that old Long-Evans rats are not defective in their capacity to develop a fever in response to brain administration of IL-1beta .

cytokine; intracerebroventricular; aging; core temperature; nervous system; immune system


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